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首页> 外文期刊>Molecular and Cellular Biology >Securin Is a Target of the UV Response Pathway in Mammalian Cells
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Securin Is a Target of the UV Response Pathway in Mammalian Cells

机译：Securin是哺乳动物细胞中紫外线反应途径的目标。

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All eukaryotic cells possess elaborate mechanisms to protect genome integrity and ensure survival after DNA damage, ceasing proliferation and granting time for DNA repair. Securin is an inhibitory protein that is bound to a protease called Separase to inhibit sister chromatid separation until the onset of anaphase. At the metaphase-to-anaphase transition, Securin is degraded by the anaphase-promoting complex or cyclosome, and Separase contributes to the release of cohesins from the chromosome, allowing for the segregation of sister chromatids to opposite spindle poles. Here we provide evidence that human Securin (hSecurin) has a novel role in cell cycle arrest after exposure to UV light or ionizing radiation. In fact, irradiation downregulated the level of hSecurin protein, accelerating its degradation via the proteasome and reducing hSecurin mRNA translation, but the presence of hSecurin is necessary for cell proliferation arrest following UV treatment. Moreover, an alteration of UV-induced hSecurin downregulation could lead directly to the accumulation of DNA damage and the subsequent development of malignant tumors.
机译：所有的真核细胞都具有完善的机制来保护基因组完整性，并确保DNA损伤后存活，停止增殖并为DNA修复留出时间。 Securin是一种抑制蛋白，与一种叫做Separase的蛋白酶结合，可以抑制姐妹染色单体分离，直到后期开始。在中期到后期的过渡过程中，Securin被促进后期的复合物或环体降解，而Separase有助于从染色体中释放粘着蛋白，从而使姐妹染色单体分离到相反的纺锤体极。在这里，我们提供证据表明，人体Securin（hSecurin）在暴露于紫外线或电离辐射后，在细胞周期停滞中具有新型作用。实际上，辐射下调了hSecurin蛋白的水平，加速了它通过蛋白酶体的降解并降低了 hSecurin mRNA的翻译，但是hSecurin的存在对于紫外线处理后细胞增殖的抑制是必需的。此外，紫外线诱导的hSecurin下调的改变可能直接导致DNA损伤的积累和随后恶性肿瘤的发展。

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