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首页> 外文期刊>Molecular and Cellular Biology >Study of Long-Distance Functional Interactions between Su(Hw) Insulators That Can Regulate Enhancer-Promoter Communication in Drosophila melanogaster
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Study of Long-Distance Functional Interactions between Su(Hw) Insulators That Can Regulate Enhancer-Promoter Communication in Drosophila melanogaster

机译：Su（Hw）绝缘子之间长距离功能相互作用的研究，该绝缘子可以调节果蝇的增强子-促进子之间的通讯。

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The Su(Hw) insulator found in the gypsy retrotransposon is the most potent enhancer blocker in Drosophila melanogaster. However, two such insulators in tandem do not prevent enhancer-promoter communication, apparently because of their pairing interaction that results in mutual neutralization. Furthering our studies of the role of insulators in the control of gene expression, here we present a functional analysis of a large set of transgenic constructs with various arrangements of regulatory elements, including two or three insulators. We demonstrate that their interplay can have quite different outcomes depending on the order of and distance between elements. Thus, insulators can interact with each other over considerable distances, across interposed enhancers or promoters and coding sequences, whereby enhancer blocking may be attenuated, cancelled, or restored. Some inferences concerning the possible modes of insulator action are made from collating the new data and the relevant literature, with tentative schemes illustrating the regulatory situations in particular model constructs.
机译：在吉普赛人反转录转座子中发现的Su（Hw）绝缘体是果蝇中最有效的增强剂阻滞剂。但是，两个这样的绝缘体串联起来并不能阻止增强子与启动子的通信，这显然是因为它们的配对相互作用导致相互中和。为了进一步研究绝缘子在基因表达控制中的作用，在这里，我们对一大组具有各种调节元件排列的转基因构建体进行功能分析，包括两个或三个绝缘子。我们证明，根据元素的顺序和元素之间的距离，它们的相互作用可能会产生完全不同的结果。因此，绝缘子可以在相当大的距离上，在插入的增强子或启动子和编码序列之间相互作用，从而增强子的阻断可以被减弱，消除或恢复。通过核对新数据和相关文献，并通过尝试性方案说明特定模型构造中的调节情况，可以得出一些有关绝缘子作用方式的推断。

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