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首页> 外文期刊>RSC Advances >Core–shell structured nanospheres for photothermal ablation and pH-triggered drug delivery toward synergistic cancer therapy
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Core–shell structured nanospheres for photothermal ablation and pH-triggered drug delivery toward synergistic cancer therapy

机译：核-壳结构的纳米球，用于光热消融和pH触发的药物递送，用于协同癌症治疗

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CuS nanoparticles capped with a long-chain carboxylic acid were synthesized and conjugated with chitosan (CS) via N-hydroxysuccinimide. The anticancer drug doxorubicin (DOX) was then encapsulated by hydrophobic interaction, producing pH-responsive CuS(DOX)@CS nanospheres with photothermal conversion properties for controllable drug release and photothermal ablation (PTA). On the one hand, the encapsulated CuS nanoparticles can absorb NIR photons and be heated efficiently. On the other hand, the entrapped DOX can be released from the swollen CuS(DOX)@CS nanospheres caused by stretched oleoyl-CS chains at lowered pH. Combining chemotherapy and PTA, the biocompatible CuS(DOX)@CS nanospheres can provide synergistic cancer treatment, as evidenced by both in vitro and in vivo experiments. This study gives new insights into developing multifunctional drug delivery agents for cancer nanotherapeutics.
机译：合成了被长链羧酸封端的CuS纳米粒子，并通过N -羟基琥珀酰亚胺与壳聚糖（CS）共轭。然后通过疏水相互作用将抗癌药阿霉素（DOX）封装起来，产生具有光热转化特性的pH响应CuS（DOX）@CS纳米球，可控药物释放和光热消融（PTA）。一方面，封装的CuS纳米粒子可以吸收NIR光子并被有效地加热。另一方面，被包裹的DOX可以从在较低的pH下伸展的油酰-CS链引起的溶胀的CuS（DOX）@CS纳米球中释放出来。生物相容性CuS（DOX）@CS纳米球结合化学疗法和PTA，可以提供协同的癌症治疗，这在体外和体内实验中都得到了证明。这项研究为开发用于癌症纳米治疗的多功能药物输送剂提供了新见识。

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