Self-emulsification of eugenol by modified rice proteins to design nano delivery systems for controlled release of caffeic acid phenethyl ester

Tao Wang; Huaiqiong Chen; Ren Wang; Zhengxing Chen; Qixin Zhong

首页> 外文期刊>RSC Advances >Self-emulsification of eugenol by modified rice proteins to design nano delivery systems for controlled release of caffeic acid phenethyl ester

【24h】

Self-emulsification of eugenol by modified rice proteins to design nano delivery systems for controlled release of caffeic acid phenethyl ester

机译：修饰的大米蛋白对丁香酚的自我乳化作用，以设计用于控制咖啡酸苯乙酯释放的纳米传递系统

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The self-emulsification of oils containing dissolved solutes is not only an intriguing phenomenon but is also of practical interest in the delivery of agricultural chemicals and drugs. Herein, a facile one-step self-emulsification of eugenol with tunable release rates of encapsulated lipophilic compounds was enabled simply by gently mixing eugenol with modified rice proteins (MRPs). Due to binding with eugenol by hydrophobic interactions lowering the oil/water interfacial tension, MRPs underwent secondary structure changes and precipitated on eugenol droplets of nanoscale. Increasing the MRP?:?eugenol ratio enabled the formation of more porous interfacial films to increase the first-order release rate of eugenol and the resultant anti-proliferation activity of encapsulated caffeic acid phenethyl ester (CAPE) against HTC-116 human colorectal cancer cells. Therefore, novel emulsions with varied interfacial structures can be fabricated utilizing MRPs to control release characteristics and bioactivity of lipophilic compounds.

机译：含有溶解性溶质的油的自乳化不仅是一种引人入胜的现象，而且在输送农药和药物方面也具有实际意义。在此，只需将丁香酚与修饰的大米蛋白（MRPs）轻轻混合，即可实现丁香酚的便捷的一步自乳化，具有可调的包封的亲脂性化合物释放速率。由于通过疏水相互作用与丁香酚的结合降低了油/水的界面张力，因此MRP经历了二级结构变化并沉淀在纳米级的丁香酚液滴上。增加MRP？：？丁子香酚的比例可以形成更多的多孔界面膜，从而增加丁子香酚的一级释放速率以及由此产生的胶囊化咖啡酸苯乙酯（CAPE）对HTC-116人结肠直肠癌细胞的抗增殖活性。因此，可以利用MRP来控制亲脂性化合物的释放特性和生物活性，从而制备出具有不同界面结构的新型乳液。

著录项

来源
《RSC Advances》 |2017年第79期|共9页
作者
Tao Wang; Huaiqiong Chen; Ren Wang; Zhengxing Chen; Qixin Zhong;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. Self-emulsification of eugenol by modified rice proteins to design nano delivery systems for controlled release of caffeic acid phenethyl ester [J] . Wang Tao, Chen Huaiqiong, Wang Ren, RSC Advances . 2017,第79期

机译：改性水稻蛋白质的丁香酚的自乳化设计纳米递送系统，用于控制野生酸苯乙烷的控制释放
2. Poly (acrylic acid) grafted gelatin nanocarriers as swelling controlled drug delivery system for optimized release of paclitaxel from modified gelatin [J] . Pal Anjali, Bajpai Jaya, Bajpai A. K. Journal of drug delivery science and technology . 2018,第期

机译：聚（丙烯酸）接枝明胶纳米载体作为溶胀控制的药物递送系统，用于优化紫杉醇的紫杉醇释放
3. Functionalization of ginger derived nanoparticles with chitosan to design drug delivery system for controlled release of 5-amino salicylic acid (5-ASA) in treatment of inflammatory bowel diseases: An in vitro study [J] . Markam Riya, Bajpai A. K. Reactive & Functional Polymers . 2020,第Apra期

机译：用壳聚糖将生姜纳米颗粒功能化，以设计药物释放系统以控制5-氨基水杨酸（5-ASA）的释放，治疗炎症性肠病：一项体外研究
4. Caffeic Acid Phenethyl Ester Protect Mice Hepatic Damage Against Cadmium Exposure [C] . Fuxin Chen, Pin Gong International Conference on Environment Science and Biotechnology . 2013

机译：咖啡酸苯乙烯酯保护小鼠肝脏损伤对镉暴露
5. Modified Indian gums as hydrophilic matrices for oral controlled release drug delivery systems. [D] . Baweja, Jitendra. 2015

机译：改性印度树胶作为口服控释药物递送系统的亲水性基质。
6. Sulfonate-modified phenylboronic acid-rich nanoparticles as a novel mucoadhesive drug delivery system for vaginal administration of protein therapeutics: improved stability, mucin-dependent release and effective intravaginal placement [O] . ChunYan Li, ZhiGang Huang, ZheShuo Liu, 1988

机译：磺酸修饰的富含苯基硼酸的纳米颗粒，作为用于阴道给药的蛋白质治疗药物的新型粘膜粘附药物递送系统：提高了稳定性，黏蛋白依赖性释放和有效的阴道内放置
7. Self-emulsification of eugenol by modified rice proteins to design nano delivery systems for controlled release of caffeic acid phenethyl ester [O] . Tao Wang, Huaiqiong Chen, Ren Wang, 2017

机译：改性水稻蛋白质的丁香酚的自乳化设计纳米递送系统，用于控制野生酸苯乙烷的控制释放
8. Synthesis of a Series of Caffeic Acid Phenethyl Amide (CAPA) Fluorinated Derivatives: Comparison of Cytoprotective Effects to Caffeic Acid Phenethyl Ester (CAPE). [R] . Yang, J., Marriner, G. A., Wang, X., 2010

机译：一系列咖啡酸苯乙酰胺（Capa）氟化衍生物的合成：对咖啡酸苯乙酯（CapE）的细胞保护作用的比较。

Self-emulsification of eugenol by modified rice proteins to design nano delivery systems for controlled release of caffeic acid phenethyl ester

摘要

著录项

相似文献

相关主题

期刊订阅