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首页> 外文期刊>RSC Advances >Counterion coupled (COCO) gemini surfactant capped Ag/Au alloy and Ag@Au core–shell nanoparticles for cancer therapy
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Counterion coupled (COCO) gemini surfactant capped Ag/Au alloy and Ag@Au core–shell nanoparticles for cancer therapy

机译：抗衡离子偶联（COCO）双子表面活性剂包覆的Ag / Au合金和Ag @ Au核壳纳米粒子用于癌症治疗

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Hybrid silver (Ag)–gold (Au) nanoparticles (NPs) with different sizes and compositions were synthesized. Ag/Au alloy and Ag@Au core–shell type NPs were prepared from Ag and Au with various ratios using the COCO gemini surfactant, 1,6-bis ( N , N -hexadecyldimethylammonium) adipate (COCOGS), 16-6-16 as a stabilizer. The formation of the Ag/Au alloy and Ag@Au core–shell was confirmed by UV-visible absorption spectroscopy, high-resolution transmission electron microscopy (HRTEM), energy-dispersive X-ray spectroscopy (EDX) and selected area electron diffraction (SAED) patterns. Depending on the composition of the Ag/Au alloy NPs, the λ _(max) values varied from 408 nm to 525 nm. FTIR measurements were used to evaluate the adsorption of the COCO gemini surfactant (16-6-16) on the Ag/Au alloy and Ag@Au core–shell surface. In this present work, we study how to achieve the stability and activity of the COCO gemini surfactant (16-6-16) capped Ag/Au alloy and Ag@Au core–shell NPs for developing novel anti-cancer agents by evaluating their potentials in the Hep-2 cell line model. Thus the developed core–shell NPs were possibly involved in inducing cytotoxicity followed by inhibition of cell proliferation to the cancer cells with apoptosis induction. The developed core–shell NPs might serve as highly applicable agents in the development of next-generation cancer chemotherapeutic agents.
机译：合成了具有不同大小和组成的杂化银（Ag）-金（Au）纳米颗粒（NPs）。 Ag / Au合金和Ag @ Au核壳型NPs是使用可可双子表面活性剂，1,6-双（N，N-十六烷基二甲基铵）己二酸酯（COCOGS），16-6-16由Ag和Au以不同比例制备的作为稳定剂。 Ag / Au合金和Ag @ Au核壳的形成已通过紫外可见吸收光谱，高分辨率透射电子显微镜（HRTEM），能量色散X射线光谱（EDX）和选定区域电子衍射（ SAED）模式。取决于Ag / Au合金NP的组成，λ_（max）值在408nm至525nm之间变化。 FTIR测量用于评估COCO双子表面活性剂（16-6-16）在Ag / Au合金和Ag @ Au核-壳表面上的吸附。在本工作中，我们研究如何通过评估潜在的潜力来获得可可双子表面活性剂（16-6-16）封端的Ag / Au合金和Ag @ Au核壳NP的稳定性和活性，以开发新型抗癌药在Hep-2细胞系模型中因此，发达的核壳NP可能参与诱导细胞毒性，随后通过凋亡诱导抑制细胞向癌细胞的增殖。发达的核壳NPs可以作为下一代癌症化疗药物开发中的高度适用药物。

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