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首页> 外文期刊>RSC Advances >Counterion coupled (COCO) gemini surfactant capped Ag/Au alloy and Ag@Au core-shell nanoparticles for cancer therapy
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Counterion coupled (COCO) gemini surfactant capped Ag/Au alloy and Ag@Au core-shell nanoparticles for cancer therapy

机译：抗衡离子偶联（可可）Gemini表面活性剂封端Ag / Au合金和Ag / Au核心 - 壳纳米粒子用于癌症治疗

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Hybrid silver (Ag)-gold (Au) nanoparticles (NPs) with different sizes and compositions were synthesized. Ag/Au alloy and Ag@Au core-shell type NPs were prepared from Ag and Au with various ratios using the COCO gemini surfactant, 1,6-bis (N,N-hexadecyldimethylammonium) adipate (COCOGS), 16-6-16 as a stabilizer. The formation of the Ag/Au alloy and Ag@Au core-shell was confirmed by UV-visible absorption spectroscopy, high-resolution transmission electron microscopy (HRTEM), energy-dispersive X-ray spectroscopy (EDX) and selected area electron diffraction (SAED) patterns. Depending on the composition of the Ag/Au alloy NPs, the lambda(max) values varied from 408 nm to 525 nm. FTIR measurements were used to evaluate the adsorption of the COCO gemini surfactant (16-6-16) on the Ag/Au alloy and Ag@Au core-shell surface. In this present work, we study how to achieve the stability and activity of the COCO gemini surfactant (16-6-16) capped Ag/Au alloy and Ag@Au core-shell NPs for developing novel anti-cancer agents by evaluating their potentials in the Hep-2 cell line model. Thus the developed core-shell NPs were possibly involved in inducing cytotoxicity followed by inhibition of cell proliferation to the cancer cells with apoptosis induction. The developed core-shell NPs might serve as highly applicable agents in the development of next-generation cancer chemotherapeutic agents.
机译：合成具有不同尺寸和组合物的杂种银（Ag）-Gold（Au）纳米颗粒（NPS）。 Ag / Au合金和Ag @ Au核 - 壳型NPS由Ag和Au使用各种比率使用Coco Gemini表面活性剂，1,6-双（N，N-Hexadecyldimethylamium）己二酸（Cocogs），16-6-16作为稳定剂。通过UV可见吸收光谱，高分辨率透射电子显微镜（HRTEM），能量分散X射线光谱（EDX）和选择的区域电子衍射确认了AG / Au合金和Ag / Au核壳的形成。萨德）模式。根据Ag / Au合金NP的组成，Lambda（MAX）值从408nm变化至525nm。使用FTIR测量来评估可可Gemini表面活性剂（16-6-16）对Ag / Au合金和Ag核心壳表面的吸附。在本工作中，我们研究了如何通过评估其潜力来实现Coco Gemini表面活性剂（16-6-16）封端的型Coci Gemini表面活性剂（16-6-16）封端的Ag / Au合金和Ag @ Au核心壳NPS的稳定性和活动在HEP-2细胞系模型中。因此，发育的核 - 壳NPS可能涉及诱导细胞毒性，然后抑制细胞增殖与细胞凋亡诱导的癌细胞。开发的核心壳NPS可以作为高度适用的药剂在下一代癌症化学治疗剂的发展中。

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    《RSC Advances》 |2019年第65期|共16页
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  • 正文语种 eng
  • 中图分类 化学;
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