A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A

Jingjing Xu; Kai Wang; Jinlong Wu

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A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A

机译：溴酪氨酸衍生的生物碱苯丙氨酸A的短而有效的全合成

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Psammaplysene A, an inhibitor of FOXO1a-mediated nuclear export, has been synthesized by a concise and improved route from tyrosine-derived acid and amine fragments which were easily constructed using commercially available p -hydroxybenzaldehyde and tyramine as starting material, respectively. The strategy provides an efficient access of psammaplysene analogues that can be explored for potential pharmaceutical or biological activities.

机译：通过简化和改进的途径，由酪氨酸衍生的酸和胺片段合成了FOXO1a介导的核出口抑制剂，即邻苯二甲酚A，它们分别使用可商购的对羟基苯甲醛和酪胺作为起始原料容易地构建。该策略提供了可用于潜在的药物或生物活性的对苯二酚类似物的有效利用。

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《RSC Advances》 |2018年第25期|共3页
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Jingjing Xu; Kai Wang; Jinlong Wu;
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1. A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A [J] . Xu Jingjing, Wang Kai, Wu Jinlong RSC Advances . 2018,第25期

机译：溴吡氨酸衍生的生物碱PSammaplysene a的简短和有效的总合成
2. A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A [J] . Jingjing Xu, Kai Wang, Jinlong Wu RSC Advances . 2018,第25期

机译：溴酪氨酸衍生的生物碱苯丙氨酸A的短而有效的全合成
3. A Short, Efficient, and Stereoselective Total Synthesis of a Pyrrolidine Alkaloid: (-)-Codonopsinine [J] . Jangari Santhosh Reddy, Batchu Venkateswara Rao The Journal of Organic Chemistry . 2007,第6期

机译：吡咯烷生物碱的短，高效和立体选择性全合成：（-）-Codonopsinine
4. Short Total Synthesis of the Marine Alkaloid Subarine [C] . Matthias Lotter, Franz Bracher Scientia pharmaceutica . 2009

机译：海洋生物碱潜艇的短全合成
5. Part I: The first regio- and atropdiastereoselective total synthesis of the dimeric indole alkaloid (+)-dispegatrine, as well as the first total synthesis of the sarpagine alkaloids (+)-spegatrine, lochvinerine, (+)-lochneram and an improved total synthesis of (+)-10-methoxyvellosimine, (+)-lochnerine and (+)-sarpagine. Part II: Studies directed toward the total synthesis of the carbon-19 methyl substituted sarpagine-macroline alkaloids (+)-macro-salhine chloride as well as macrocarpine A, B and C. [D] . Edwankar, Chitra R. 2011

机译：第一部分：二聚吲哚生物碱（+）-dispegatrine的第一个区域和对映异构选择性全合成，以及sarpagine生物碱（+）-spegatrine，lochvinerine，（+）-lochneram的第一个全合成（+）-10-甲氧基玻璃素胺，（+）-氯精胺和（+）-sarpagine的合成。第二部分：研究碳19甲基取代的沙雷帕金-大麦碱生物碱（+）-大-沙丁鱼碱氯化物以及大芸香碱A，B和C的总合成。
6. Stereospecific Approach to the Synthesis of Ring-A Oxygenated Sarpagine Indole Alkaloids. Total Synthesis of the Dimeric Indole Alkaloid P-(+)-Dispegatrine and Six Other Monomeric Indole Alkaloids [O] . Chitra R. Edwankar, Rahul V. Edwankar, Ojas A. Namjoshi, -1

机译：立体定向方法合成环A氧化的Sarpagine吲哚生物碱。二聚吲哚生物碱P-（+）-Dispegatrine和其他六个单体吲哚生物碱的全合成
7. A Short, Efficient, and Stereoselective Total Synthesis of a Pyrrolidine Alkaloid: (-)-Codonopsinine [O] . -1

机译：吡咯烷生物碱的短，高效，立体选择性合成：（ - ） - 致苯并二植物

A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A

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