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首页> 外文期刊>RSC Advances >“Turn on” room-temperature phosphorescent biosensors for detection of hyaluronic acid based on manganese-doped ZnS quantum dots
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“Turn on” room-temperature phosphorescent biosensors for detection of hyaluronic acid based on manganese-doped ZnS quantum dots

机译：基于锰掺杂的ZnS量子点的“开启”室温磷光生物传感器，用于检测透明质酸

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摘要

Biosensors based on excellent optical properties of quantum dots (QDs) nanohybrids are efficient for biological detection. In this work, a room-temperature phosphorescent (RTP) PDAD–Mn–ZnS QDs biosensor was constructed with poly(diallyldimethylammonium chloride) (PDAD) as the modifier of MPA-capped Mn–ZnS QDs, and used to detect hyaluronic acid (HA). The newly-added HA induced severe electrostatic interaction with PDAD–Mn–ZnS QDs, leading to the aggregation between PDAD–Mn–ZnS QDs and HA and thereby enhancing RTP. The enhancement of RTP was proportional to the HA concentrations within certain ranges. On this basis, a high-performance HA sensor was built and this sensor had a detection limit of 0.03 μg mL?1 and a detection range of 0.08–2.8 μg mL?1. This proposed RTP sensor can avoid interferences from the background fluorescence or scattering light of the matrix that are encountered in spectrofluorometry. Thus, this biosensor is potentially suitable for detection of HA in real samples without complicated pretreatment.
机译：基于量子点（QD）纳米杂化物优异光学特性的生物传感器对于生物检测非常有效。在这项工作中，使用聚二烯丙基二甲基氯化铵（PDAD）作为MPA封端的Mn–ZnS QD的修饰剂，构建了室温磷光（RTP）PDAD–Mn–ZnS QDs生物传感器，并用于检测透明质酸（HA）。 ）。新添加的HA与PDAD-Mn-ZnS QDs产生严重的静电相互作用，导致PDAD-Mn-ZnS QDs与HA之间聚集，从而增强了RTP。 RTP的增强与一定范围内的HA浓度成正比。在此基础上，构建了高性能的HA传感器，该传感器的检出限为0.03μgmL ？1 ，检出范围为0.08–2.8μgmL < small> ？1 。提出的RTP传感器可以避免在荧光光谱法中遇到的背景荧光或基质散射光的干扰。因此，该生物传感器潜在地适合于在不进行复杂预处理的情况下检测真实样品中的HA。

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