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首页> 外文期刊>RSC Advances >A highly selective fluorescent probe for human NAD(P)H:quinone oxidoreductase 1 (hNQO1) detection and imaging in living tumor cells
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A highly selective fluorescent probe for human NAD(P)H:quinone oxidoreductase 1 (hNQO1) detection and imaging in living tumor cells

机译：一种用于人类NAD（P）H：醌氧化还原酶1（hNQO1）检测和成像的活肿瘤细胞的高选择性荧光探针

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摘要

Human NAD(P)H:quinone oxidoreductase (hNQO1) can be used as a biomarker for the early diagnosis of cancer. In this article, a novel fluorescent probe 1 for detecting hNQO1 was designed and synthesized by using 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF) derivative (TCF-OH) as a fluorophore and quinone propionic acid (QPA) as a recognition group. The probe, which has high selectivity for hNQO1 and a Stokes shift of about 117 nm, shows a linear relationship with hNQO1 concentrations in the range of 0.25–3 μg ml ~(?1) with the color changes from yellow to red and was successfully applied to intracellular hNQO1 imaging.
机译：人NAD（P）H：醌氧化还原酶（hNQO1）可用作癌症的早期诊断的生物标志物。本文以2-二氰基亚甲基-3-氰基-4,5,5-三甲基-2,5-二氢呋喃（TCF）衍生物（TCF-OH）为原料，设计合成了一种检测hNQO1的新型荧光探针1。荧光团和醌丙酸（QPA）作为识别基团。该探针对hNQO1的选择性高，斯托克斯位移约为117 nm，与hNQO1浓度在0.25–3μgml〜（？1）范围内呈线性关系，并且颜色从黄色变为红色，并且成功应用于细胞内hNQO1成像。

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