A highly selective fluorescent probe for human NAD(P)H:quinone oxidoreductase 1 (hNQO1) detection and imaging in living tumor cells

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A highly selective fluorescent probe for human NAD(P)H:quinone oxidoreductase 1 (hNQO1) detection and imaging in living tumor cells

机译：用于人NAD（P）H的高选择性荧光探针：醌氧化还原酶1（HNQO1）在活肿瘤细胞中检测和成像

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Human NAD(P)H:quinone oxidoreductase (hNQO1) can be used as a biomarker for the early diagnosis of cancer. In this article, a novel fluorescent probe 1 for detecting hNQO1 was designed and synthesized by using 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF) derivative (TCF-OH) as a fluorophore and quinone propionic acid (QPA) as a recognition group. The probe, which has high selectivity for hNQO1 and a Stokes shift of about 117 nm, shows a linear relationship with hNQO1 concentrations in the range of 0.25-3 mu g ml(-1) with the color changes from yellow to red and was successfully applied to intracellular hNQO1 imaging.

机译：人NAD（P）H：醌氧化还原酶（HNQO1）可用作早期诊断癌症的生物标志物。在本文中，通过使用2-二氰基甲基-3-氰基-4,5,5-三甲基-2,5-二氢呋喃（TCF）衍生物（TCF-OH）设计和合成用于检测HNQO1的新型荧光探针1。荧光团和醌丙酸（QPA）作为识别组。对HNQO1具有高选择性的探针和约117nm的斯托克斯偏移，显示出与0.25-3μg（-1）范围内的HNQO1浓度的线性关系，颜色从黄色变为红色并成功地适用于细胞内HNQO1成像。

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《RSC Advances》 |2019年第46期|共5页
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1. A highly selective fluorescent probe for human NAD(P)H:quinone oxidoreductase 1 (hNQO1) detection and imaging in living tumor cells [J] . RSC Advances . 2019,第46期

机译：用于人NAD（P）H的高选择性荧光探针：醌氧化还原酶1（HNQO1）在活肿瘤细胞中检测和成像
2. Correction: A highly selective fluorescent probe for human NAD(P)H:quinone oxidoreductase 1 (hNQO1) detection and imaging in living tumor cells [J] . Ya Zhu, Jialing Han, Qian Zhang, RSC Advances . 2019,第59期

机译：校正：一种用于人类NAD（P）H：醌氧化还原酶1（hNQO1）检测和成像的活肿瘤细胞的高选择性荧光探针
3. A highly selective fluorescent probe for human NAD(P)H:quinone oxidoreductase 1 (hNQO1) detection and imaging in living tumor cells [J] . Ya Zhu, Jialing Han, Qian Zhang, RSC Advances . 2019,第46期

机译：一种用于人类NAD（P）H：醌氧化还原酶1（hNQO1）检测和成像的活肿瘤细胞的高选择性荧光探针
4. Upregulation of NAD(P)H:Quinone Oxidoreductase (NQO1) in Glial Cells of 6-Hydroxydopamine-Lesioned Substantia Nigra in the Rat [C] . Andrea C. Kil, Benjamin Drukarch, Allert J. Jonker, Triennial Meeting of the International Basal Ganglia Society . 2009

机译：NAD（P）H：醌氧化还原酶（NQO1）在大鼠6-羟基多胺 - 损伤的胶质细胞中的喹啉氧化还原酶（NQO1）
5. The role of NAD(P)H:quinone oxidoreductase 1 in non-small cell lung cancer tumorigenesis and lung cancer stem cell maintenance [D] . Madajewski, Brian. 2016

机译：NAD（P）H：醌氧化还原酶1在非小细胞肺癌的发生和肺癌干细胞维持中的作用
6. Covalent-Assembly Based Fluorescent Probes for Detection of hNQO1 and Imaging in Living Cells [O] . Jialing Han, Longhao Cheng, Ya Zhu, 2020

机译：基于共价组装的荧光探针用于检测HNQO1和活细胞成像
7. Correction: A highly selective fluorescent probe for human NAD(P)H:quinone oxidoreductase 1 (hNQO1) detection and imaging in living tumor cells [O] . Ya Zhu, Jialing Han, Qian Zhang, 2019

机译：校正：用于人NAD的高度选择性荧光探针（P）H：醌氧化还原酶1（HNQO1）在活肿瘤细胞中检测和成像
8. Subunits of Highly Fluorescent Protein R-phycoerythrin as Probes for Cell Imaging and Single Molecule Detection Doctoral thesis [R] . Isailovic, D. 2005

机译：高荧光蛋白R-藻红蛋白亚基作为细胞成像和单分子检测的探针博士论文

A highly selective fluorescent probe for human NAD(P)H:quinone oxidoreductase 1 (hNQO1) detection and imaging in living tumor cells

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