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首页> 外文期刊>The journal of immunology >Role of Metabolism in the Immunobiology of Regulatory T Cells
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Role of Metabolism in the Immunobiology of Regulatory T Cells

机译：代谢在调节性T细胞免疫生物学中的作用

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摘要

Intracellular metabolism is central to cell activity and function. CD4+CD25+ regulatory T cells (Tregs) that express the transcription factor FOXP3 play a pivotal role in the maintenance of immune tolerance to self. Recent studies showed that the metabolism and function of Tregs are influenced significantly by local environmental conditions and the availability of certain metabolites. It also was reported that defined metabolic programs associate with Treg differentiation, expression of FOXP3, and phenotype stabilization. This article reviews how metabolism modulates FOXP3 expression and Treg function, what environmental factors are involved, and how metabolic manipulation could alter Treg frequency and function in physiopathologic conditions.
机译：细胞内代谢对于细胞活性和功能至关重要。表达转录因子FOXP3的CD4 + CD25 +调节性T细胞（Treg）在维持对自身的免疫耐受中起关键作用。最近的研究表明，Tregs的代谢和功能受当地环境条件和某些代谢物的可用性的显着影响。还据报道，确定的代谢程序与Treg分化，FOXP3的表达和表型稳定有关。本文回顾了代谢如何调节FOXP3表达和Treg功能，涉及的环境因素，以及在生理病理条件下代谢操纵如何改变Treg频率和功能。

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