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首页> 外文期刊>Journal of Clinical Microbiology >Neisseria gonorrhoeae strains inhibited by vancomycin in selective media and correlation with auxotype.
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Neisseria gonorrhoeae strains inhibited by vancomycin in selective media and correlation with auxotype.

机译：万古霉素在选择培养基中抑制淋病奈瑟氏球菌菌株，并与辅助型相关。

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Strains of Neisseria gonorrhoeae that failed to grow on Thayer-Martin (T-M) and Martin-Lewis (M-L) media accounted for 2.0% of isolates at the University of Colorado Hospital and its Venereal Disease Clinic. A total of 31 inhibited and 31 control strains were compared by agar dilution testing for their susceptibilities to 13 antimicrobial agents used for treatment or in selective media. All 62 isolates were resistant to lincomycin, colistin, nystatin, amphotericin B, trimethoprim lactate, polymyxin B, and anisomycin. Vancomycin was the inhibitory antibiotic for N. gonorrhoeae in both T-M and M-L media. The vancomycin-inhibited strains were also significantly more sensitive to penicillin and ampicillin than were the control strains (P less than 0.001). The presence of the other antibiotics in selective media did not affect the minimum inhibitory concentrations of vancomycin for gonococci. All 31 inhibited strains were sensitive to 8.0 micrograms of vancomycin per ml, and 26 of these were sensitive to 2.0 microgram/ml. Decreasing the size of inoculum of gonococci results in greater inhibition by any given concentration of vancomycin. The vancomycin-sensitive strains contained significantly more arginine- hypoxanthine-, and uracil-requiring auxotypes (28 out of 31) than did the control strains (9 out of 31). As with T-M medium, some strains of gonococci will be missed when M-L medium with 4.0 micrograms of vancomycin per ml is the only medium used for the diagnosis of gonorrhea. This may be of particular importance in the confirmation of disseminated infection with Arg- Hyx- Ura- auxotypes of N. gonorrhoeae when cultures of blood, joint fluid, or skin lesions are negative.
机译：未能在Thayer-Martin（T-M）和Martin-Lewis（M-L）培养基上生长的淋病奈瑟氏球菌菌株占科罗拉多大学医院及其性病研究所的2.0％分离株。通过琼脂稀释测试比较了总共31个抑制菌株和31个对照菌株与13种用于治疗或在选择性培养基中使用的抗菌剂的敏感性。所有62种分离株均对林可霉素，粘菌素，制霉菌素，制霉菌素B，两性霉素B，乳酸甲氧苄啶，多粘菌素B和茴香霉素具有抗性。万古霉素在T-M和M-L培养基中都是淋病奈瑟菌的抑制性抗生素。与对照菌株相比，抑制万古霉素的菌株对青霉素和氨苄青霉素的敏感性也显着更高（P小于0.001）。选择性培养基中其他抗生素的存在不影响万古霉素对淋球菌的最低抑制浓度。所有31个抑制菌株均对每毫升8.0微克万古霉素敏感，其中26个对2.0微克/毫升敏感。任何给定浓度的万古霉素均可降低淋球菌接种量，从而产生更大的抑制作用。对万古霉素敏感的菌株比对照菌株（31个中的9个）含有更多的精氨酸，次黄嘌呤和需要尿嘧啶的辅助型（31个中的28个）。与T-M培养基一样，当每毫升含4.0微克万古霉素的M-L培养基是唯一用于淋病诊断的培养基时，会漏掉一些淋球菌。当血液，关节液或皮肤病变的培养阴性时，这对于确认淋病奈瑟菌的Arg-Hyx-Ura-血型的弥散性感染的确认可能特别重要。

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