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首页> 外文期刊>Journal of Clinical Microbiology >Immune reactivity to fractionated Leishmania aethiopica antigens during active human infection.
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Immune reactivity to fractionated Leishmania aethiopica antigens during active human infection.

机译：在活跃的人类感染过程中，对分级分离的埃塞俄比亚利什曼原虫抗原的免疫反应性。

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摘要

Fractionated antigen preparations of Leishmania aethiopica parasites were used to stimulate the peripheral blood lymphocytes of patients with active cutaneous leishmaniasis. In assays measuring lymphocyte proliferation, 9 of 10 patients with similar clinical presentations of infection responded in a similar pattern to the fractionated antigens. Marked proliferation was observed in response to antigen fractions with molecular masses of 43 to 36, 33 to 27, and less than 22 kDa. The induction of relatively high levels of gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) was also observed in responses to these same three antigen fractions. In contrast, the proliferative, IFN-gamma, and TNF-alpha responses of patient lymphocytes to antigens with a molecular mass greater than 60 kDa were uniformly low. The results of this study suggest that the antigens of Leishmania parasites, which are recognized by T cells in patients with active cutaneous leishmaniasis, may be partitioned in the lower-molecular-mass antigenic determinants associated with whole-parasite preparations. The observed association between antigen-induced proliferation and IFN-gamma and TNF-alpha production may be indicative of potential disease-limiting immune effector activities which have developed during infection.
机译：分离的埃塞俄比亚利什曼原虫寄生虫抗原制剂用于刺激患有活动性皮肤利什曼病的患者的外周血淋巴细胞。在测量淋巴细胞增殖的测定中，10名具有相似临床感染表现的患者中有9名对分级抗原的反应相似。响应于分子量为43至36、33至27和小于22 kDa的抗原组分，观察到明显的增殖。在对这三个抗原部分的反应中也观察到了相对较高水平的γ-干扰素（IFN-γ）和肿瘤坏死因子α（TNF-α）的诱导。相反，患者淋巴细胞对分子量大于60 kDa的抗原的增殖，IFN-γ和TNF-α反应始终较低。这项研究的结果表明，在活跃的皮肤利什曼病患者中，T细胞可以识别利什曼原虫的抗原，该抗原可能会在与全寄生虫制剂相关的低分子质量抗原决定簇中分配。观察到的抗原诱导的增殖与IFN-γ和TNF-α产生之间的关联可能表明在感染期间已经发展出潜在的疾病限制免疫效应子活性。

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