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首页> 外文期刊>Journal of Clinical Microbiology >New Pathogenicity Marker Found in the Plasticity Region of the Helicobacter pylori Genome
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New Pathogenicity Marker Found in the Plasticity Region of the Helicobacter pylori Genome

机译：在幽门螺杆菌基因组可塑性区域发现新的致病性标记

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Comparison of gastric carcinoma and gastritis isolates showed the presence of genes, probably carcinoma associated (JHP947 and JHP940), that are situated in a Helicobacter pylori genome region (45 kb in J99 and 68 kb in 26695) called the “plasticity region.” This region presents a great variability of DNA sequences. We investigated, by PCR, the presence of the JHP940 and JHP947 genes, as well as the presence of a third gene which seems to be associated with gastritis (HP986), on H. pylori strains isolated from 200 Brazilian patients, 79 of whom had gastric carcinomas and 53 of whom had duodenal ulcers, to confirm this association. Gastritis isolates (n = 68) were included as a control. We also evaluated if these genes were related to the virulence-associated cagA genotype. The present methodology did not permit definitive conclusions to be reached regarding the association between the JHP940 gene and gastric carcinoma or between the HP986 gene and gastritis. However, we showed that the JHP947 gene might be implicated in the development of both duodenal ulcer and gastric carcinoma. The presence of the JHP947 gene was associated with the cagA-positive genotype. The JHP947 gene is a novel virulence marker candidate of H. pylori.
机译：胃癌和胃炎分离株的比较显示存在基因，可能与癌相关（ JHP947 和 JHP940 ），位于幽门螺杆菌中。基因组区域（J99中为45 kb，26695中为68 kb）称为“可塑性区域”。该区域呈现出DNA序列的巨大变异性。我们通过PCR研究了 JHP940 和 JHP947 基因的存在，以及与胃炎有关的第三个基因（ HP986 ），位于 H上。从200例巴西患者中分离出幽门螺杆菌菌株，其中79例患有胃癌，53例患有十二指肠溃疡，以证实这种关联。包括胃炎分离株（ n = 68）作为对照。我们还评估了这些基因是否与毒力相关的 cagA 基因型有关。目前的方法无法得出关于 JHP940 基因与胃癌或 HP986 基因与胃炎之间关联的明确结论。然而，我们发现 JHP947 基因可能与十二指肠溃疡和胃癌的发展有关。 JHP947 基因的存在与 cagA 阳性基因型相关。 JHP947 基因是 H的新型毒力标记候选物。幽门螺旋杆菌。

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