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首页> 外文期刊>Journal of Clinical Microbiology >Genotypic and Phenotypic Characterization of Carriage and Invasive Disease Isolates of Neisseria meningitidis in Finland
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Genotypic and Phenotypic Characterization of Carriage and Invasive Disease Isolates of Neisseria meningitidis in Finland

机译：芬兰脑膜炎奈瑟氏球菌的运输和侵袭性疾病分离株的基因型和表型特征

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The relationship between carriage and the development of invasive meningococcal disease is not fully understood. We investigated the changes in meningococcal carriage in 892 military recruits in Finland during a nonepidemic period (July 2004 to January 2006) and characterized all of the oropharyngeal meningococcal isolates obtained (n = 215) by using phenotypic (serogrouping and serotyping) and genotypic (porA typing and multilocus sequence typing) methods. For comparison, 84 invasive meningococcal disease strains isolated in Finland between January 2004 and February 2006 were also analyzed. The rate of meningococcal carriage was significantly higher at the end of military service than on arrival (18% versus 2.2%; P < 0.001). Seventy-four percent of serogroupable carriage isolates belonged to serogroup B, and 24% belonged to serogroup Y. Most carriage isolates belonged to the carriage-associated ST-60 clonal complex. However, 21.5% belonged to the hyperinvasive ST-41/44 clonal complex. Isolates belonging to the ST-23 clonal complex were cultured more often from oropharyngeal samples taken during the acute phase of respiratory infection than from samples taken at health examinations at the beginning and end of military service (odds ratio [OR], 6.7; 95% confidence interval [95% CI], 2.7 to 16.4). The ST-32 clonal complex was associated with meningococcal disease (OR, 17.8; 95% CI, 3.8 to 81.2), while the ST-60 clonal complex was associated with carriage (OR, 10.7; 95% CI, 3.3 to 35.2). These findings point to the importance of meningococcal vaccination for military recruits and also to the need for an efficacious vaccine against serogroup B isolates.
机译：运输与侵袭性脑膜炎球菌病之间的关系尚未完全了解。我们调查了非流行时期（2004年7月至2006年1月）芬兰892名新兵的脑膜炎球菌携带变化，并通过表型（血清型）对所有口咽脑膜炎球菌分离株（ n = 215）进行了表征。和血清分型）和基因型（ porA 分型和多基因座序列分型）方法。为了进行比较，还分析了2004年1月至2006年2月在芬兰分离出的84种侵袭性脑膜炎球菌菌株。服兵役结束时脑膜炎球菌的携带率明显高于到达时（18％比2.2％; P <0.001）。 74％的可血清群运输分离株属于B群，而24％的血清群属于Y。大多数分离株均属于与运输相关的ST-60克隆复合体。然而，21.5％属于高侵袭性ST-41 / 44克隆复合体。来自ST-23克隆复合物的分离株在呼吸道感染急性期的口咽样本中培养的频率要比在兵役开始和结束时进行的健康检查样本中培养的频率更高（优势比[OR]，6.7; 95％置信区间[95％CI]，从2.7到16.4）。 ST-32克隆复合体与脑膜炎球菌病相关（OR，17.8; 95％CI，3.8至81.2），而ST-60克隆复合体与运输相关（OR，10.7; 95％CI，3.3至35.2）。这些发现指出了对新兵进行脑膜炎球菌疫苗接种的重要性，同时也需要针对血清群B分离株的有效疫苗。

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