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COMPOSITIONS OF VACCINES FOR TREATMENT OR PREVENTION OF INFECTION OR DISEASE, CAUSED BY Neisseria meningitidis AND/OR Neisseria gonorrhoeae, CONTAINING MUTANT PROTEIN, BINDING H FACTOR
COMPOSITIONS OF VACCINES FOR TREATMENT OR PREVENTION OF INFECTION OR DISEASE, CAUSED BY Neisseria meningitidis AND/OR Neisseria gonorrhoeae, CONTAINING MUTANT PROTEIN, BINDING H FACTOR
FIELD: medicine, pharmaceutics.;SUBSTANCE: group of inventions relate to field of biotechnology and includes immunogenic and pharmaceutical compositions for their application for treatment or prevention of infection or disease, caused by Neisseria meningitidis and/or Neisseria gonorrhoeae, as well as set for application for immune responde induction. Composition contains at least one modified protein, which binds H factor, and pharmaceutically acceptable carrier. Composition is capable of causing immune response to Neisseria meningitidis and Neisseria gonorrhoeae, when introduced to people or non-human animal. Modified protein, which binds H factor, has sequence Seq ID No: 1 with exception of modified amino acid in at least one position, which results in absence of factor H binding or at least five-fold reduction of factor H binding in comparison with protein, binding H factor, which has sequence Seq ID No: 1. Modified amino acid residue is at position 106, as determined in sequence Seq ID No:1.;EFFECT: obtaining pharmaceutical composition for treatment or prevention of infection or disease, caused by Neisseria meningitidis and/or Neisseria gonorrhoeae.;11 cl, 9 dwg, 1 tbl
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机译：领域：发明领域涉及生物技术领域，包括用于治疗或预防由脑膜炎奈瑟氏球菌和/或淋病奈瑟氏球菌引起的感染或疾病的免疫原性和药物组合物，以及免疫应答诱导的应用。组合物包含至少一种结合H因子的修饰蛋白和可药用载体。当引入人或非人动物时，该组合物能够引起对脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌的免疫应答。与H因子结合的修饰蛋白具有序列Seq ID No：1，但在至少一个位置具有修饰的氨基酸，这导致与蛋白相比不存在H因子结合或至少5倍于H因子结合的减少，是结合的H因子，具有序列Seq ID No：1。修饰的氨基酸残基位于位置106，如序列Seq ID No：1所确定。;效果：获得用于治疗或预防感染或疾病的药物组合物，由脑膜炎奈瑟菌和/或淋病奈瑟菌; 11 cl，9 dwg，1 tbl
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