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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Changing Trend in the Antibiotic Resistance Pattern of Pseudomonas Aeruginosa Isolated from Wound Swabs of Out-Patients and in-Patients of a Tertiary Care Hospital
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Changing Trend in the Antibiotic Resistance Pattern of Pseudomonas Aeruginosa Isolated from Wound Swabs of Out-Patients and in-Patients of a Tertiary Care Hospital

机译：从三级护理医院门诊病人和住院病人伤口拭子分离出的铜绿假单胞菌的抗生素耐药性模式变化趋势

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Context: Pseudomonas aeruginosa is the most common gram negative bacteria associated with nosocomial infections. Active surveillance of trends in antibiotic resistance of P. aeruginosa is necessary for the selection of appropriate antimicrobial agent for empirical therapy.Aim: To assess the rates of antibiotic resistance and multidrug resistance among P. aeruginosa isolates and to observe the trend in its resistance pattern over a period of 5 years.Materials and Methods: Pseudomonas aeruginosa isolated from wound swabs during January to June 2007 and January to June 2012 were included in the study. Isolates were identified by conventional tests and antibiotic susceptibility was determined by disc diffusion method according to CLSI guidelines.Results: A total of 307 Pseudomonas aeruginosa isolates were included in the study. Among these isolates, 165 were isolated during Jan-June 2007 and 142 were isolated during Jan-June 2012. Among in-patients, there was a significant reduction in resistance rates of the isolates to ciprofloxacin (49% to 33%), ceftazidime (50% to 33%), meropenem (35% to 19%) and imipenem (28% to 14%) in 2012. Similarly, the rate of MDR Pseudomonas aeruginosa among the in-patients decreased from 37.9% in 2007 to 23.7% in 2012 (p value 0.0241). There was no significant difference in the resistance rates of the isolates from out-patients during the two study periods.Conclusion: There was a significant decreasing trend in the resistance rates of the isolates to ciprofloxacin, ceftazidime, meropenem and imipenem. Reduction in the use of ciprofloxacin could be probable reason for the decreased resistance among P. aeruginosa isolates, which needs to be further investigated.
机译：背景：铜绿假单胞菌是与医院感染相关的最常见的革兰氏阴性细菌。积极监测铜绿假单胞菌的抗生素耐药性趋势是选择经验疗法合适的抗菌剂的目的。目的：评估铜绿假单胞菌分离物的抗生素耐药率和多药耐药性，并观察其耐药模式的趋势。材料和方法：2007年1月至2007年6月和2012年1月至2012年6月从伤口拭子中分离出的铜绿假单胞菌被纳入研究。通过常规试验鉴定出分离物，并根据CLSI指南通过圆盘扩散法测定抗生素敏感性。结果：共纳入307株铜绿假单胞菌菌株。在这些分离株中，2007年1月至6月分离出165株，2012年1月至2012年分离出142株。在住院患者中，分离株对环丙沙星的耐药率显着降低（从49％降至33％），头孢他啶（ 50％到33％），美罗培南（35％到19％）和亚胺培南（28％到14％）在2012年。同样，住院患者的MDR铜绿假单胞菌比率从2007年的37.9％下降到2007年的23.7％。 2012（p值0.0241）。在两个研究期间，门诊患者的分离株耐药率无显着差异。结论：分离株对环丙沙星，头孢他啶，美洛培南和亚胺培南的耐药率呈显着下降趋势。减少环丙沙星的使用可能是铜绿假单胞菌分离株耐药性降低的原因，有待进一步研究。

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