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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Amino Acid Profile in Oral Submucous Fibrosis: A High Performance Liquid Chromatography (HPLC) Study
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Amino Acid Profile in Oral Submucous Fibrosis: A High Performance Liquid Chromatography (HPLC) Study

机译：口腔粘膜下纤维化中的氨基酸谱：高效液相色谱（HPLC）研究

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Background: Collagen is a significant structural protein, the integrity of which is essential to be maintained for proper homeostasis. Oral submucous fibrosis (OSMF), being a collagen metabolic disorder, may be subject to changes in amino acid profiling.Aim: The present study was attempted to evaluate the amino acid profile to assess its feasibility as a biological marker in OSMF.Materials and Methods: The study group comprised of 13 patents with OSMF and the normal group comprised of 13 normal patients without associated habits or systemic disorders. Venous blood was collected from the antecubital vein, plasma was separated and the plasma was then subjected to high profile liquid chromatographic analysis.Results: The assay levels of threonine, alanine and tyrosine did not yield any significant results. The decreased assay levels of valine, Isoleucine and the increased assay level of methionine and glycine observed in group II yielded significant results in correlation with the control group. The decreased assay level seen in phenylalanine in group II and III in correlation with group IV is statistically significant.Conclusion: A few amino acids have been identified which can be used as biological markers for the severity of the disease such as valine, methionine and phenyl alanine. Large scale studies are required to elucidate the potential of these biological markers.
机译：背景：胶原蛋白是一种重要的结构蛋白，其完整性对于维持适当的体内平衡至关重要。口腔粘膜下纤维化（OSMF）是一种胶原蛋白代谢异常，可能会发生氨基酸谱变化。目的：本研究旨在评估氨基酸谱，以评估其作为OSMF中生物标记物的可行性。 ：研究组包括13项具有OSMF的专利，而正常组包括13名无相关习惯或系统性疾病的正常患者。从肘前静脉采集静脉血，分离血浆，然后对血浆进行高分辨液相色谱分析。结果：苏氨酸，丙氨酸和酪氨酸的测定水平未产生任何显着结果。在第二组中观察到的缬氨酸，异亮氨酸测定水平降低以及蛋氨酸和甘氨酸测定水平升高产生了与对照组相关的显着结果。 II，III组与IV组相关的苯丙氨酸含量下降具有统计学意义。结论：已鉴定出一些氨基酸，可以用作疾病严重程度的生物学标记，例如缬氨酸，蛋氨酸和苯基丙氨酸。需要大规模研究来阐明这些生物标记物的潜力。

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