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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparison of Efficacy and Safety of Intramuscular Piroxicam and Tramadol for Post-operative Pain in Patients Undergoing Caesarean Delivery
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Comparison of Efficacy and Safety of Intramuscular Piroxicam and Tramadol for Post-operative Pain in Patients Undergoing Caesarean Delivery

机译：剖宫产患者肌内吡罗昔康和曲马多对术后疼痛的疗效和安全性比较

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Introduction: Post-caesarean section pain can be both stressful and unfavourable. Effective and rapid reduction of pain facilitates early ambulation and care of the new born. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and opioids are used for pain relief but they are associated with adverse effects both in the mother and the child.Aim: To evaluate efficacy and safety of piroxicam and tramadol in post-caesarean section pain.Materials and Methods: Primigravidae who underwent elective caesarean section received either piroxicam 20mg or tramadol 100mg intra-muscularly, following recovery from anaesthesia. Severity of pain was assessed using Visual Analogue Scale (VAS) and side-effects to study drugs were noted. Rescue analgesic butorphanol 2mg was administered if VAS score was more than four. Patient?s satisfaction score was assessed at 12 hours post-operatively.Results: Mean age in piroxicam and tramadol groups were 23.32±3.43 and 22.03±2.0 years respectively. Significant reduction in pain was observed at 2, 4, 8, 12 and 24 hours in both groups (p<0.001). Pain relief was significant at 2, 4 and 8 hours in piroxicam group compared to tramadol. Twenty-one and 12 patients in tramadol and piroxicam groups received rescue analgesic respectively. Sedation and nausea was significantly higher in tramadol group (p<0.001), 46.66% of patients graded their satisfaction score as good and 15% as excellent in piroxicam group.Conclusion: Intra-muscular piroxicam was effective in reducing post-caesarean section pain for 24 hours with minimal side-effects compared to tramadol.
机译：简介：剖宫产后的疼痛既有压力又有不利影响。有效而迅速地减轻疼痛有助于早期移动和护理新生儿。非甾体类抗炎药（NSAIDs）和阿片类药物可缓解疼痛，但它们对母亲和儿童均具有不良影响。目的：评估吡罗昔康和曲马多在剖宫产术后疼痛中的疗效和安全性。材料和方法：麻醉后recovery愈后，行选择性剖宫产的初产妇肌内注射吡罗昔康20mg或曲马多100mg。使用视觉模拟量表（VAS）评估疼痛的严重程度，并指出研究药物的副作用。如果VAS评分大于4，则施行急救镇痛药布托啡诺2mg。术后12小时评估患者满意度。结果：吡罗昔康和曲马多组的平均年龄分别为23.32±3.43和22.03±2.0岁。两组分别在2、4、8、12和24小时观察到疼痛明显减轻（p <0.001）。与曲马多相比，吡罗昔康组在第2、4和8小时疼痛减轻明显。曲马多和吡罗昔康组分别有21例和12例患者接受了急救镇痛。曲马多组的镇静和恶心显着高于对照组（p <0.001），吡罗昔康组患者的满意度得分为46.66％，优良率为15％。结论：肌肉注射吡罗昔康可有效减少术后抑郁。与曲马多相比，剖腹产疼痛持续24小时，副作用最小。

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