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首页> 外文期刊>Journal of bacteriology >Molecular Events in the Growth Inhibition of Bacillus subtilis by d-Tyrosine
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Molecular Events in the Growth Inhibition of Bacillus subtilis by d-Tyrosine

机译：d-酪氨酸抑制枯草芽孢杆菌生长的分子事件

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The transformable strain of Bacillus subtilis strain 168 is extremely susceptible to growth inhibition by d-tyrosine. The molecular events associated with the inhibition of growth by d-tyrosine in this strain include the false feedback inhibition and probably the false repression of prephenate dehydrogenase. These effects were found to contribute to the formation of d-tyrosine-containing proteins by decreasing the intracellular concentration of l-tyrosine. Accordingly, growth inhibition of strain 168 by the d isomer of tyrosine was shown to be progressive, enduring, and delayed by prior growth on l-tyrosine. The synthesis of cellular macromolecules and viable cell count were progressively diminished in d-tyrosine-inhibited cultures. Several different enzyme activities were reduced after growth in the presence of d-tyrosine. Isotopic d-tyrosine was incorporated into cellular proteins without change of optical configuration. Long chains of cells with completed septa were observed microscopically, and therefore some cell wall effect may also be implicated.
机译：枯草芽孢杆菌菌株168的可转化菌株极易受到d-酪氨酸的生长抑制。与该菌株中的d-酪氨酸抑制生长有关的分子事件包括错误的反馈抑制和可能的错误的苯甲酸酯脱氢酶抑制。发现这些作用通过降低细胞内1-酪氨酸的浓度有助于形成含d-酪氨酸的蛋白质。因此，酪氨酸的d异构体对菌株168的生长抑制被证明是进行性的，持久的并且由于先前在1-酪氨酸上的生长而延迟。在d-酪氨酸抑制的培养物中，细胞大分子的合成和活细胞计数逐渐减少。在d-酪氨酸存在下生长后，几种不同的酶活性降低。同位素d-酪氨酸被掺入到细胞蛋白中而没有改变光学构型。在显微镜下观察到具有完整隔片的长链细胞，因此也可能涉及一些细胞壁效应。

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