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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Clinicopathological Analysis of Glomerular Disease of Adult Onset Nephrotic Syndrome in an Indian Cohort- A Retrospective Study EC25-EC30
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Clinicopathological Analysis of Glomerular Disease of Adult Onset Nephrotic Syndrome in an Indian Cohort- A Retrospective Study EC25-EC30

机译：印度队列成人肾病综合征肾小球疾病的临床病理分析-一项回顾性研究EC25-EC30

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Introduction: Primary glomerular disease presenting with adult onset nephrotic syndrome are a major cause of chronic renal failure worldwide. The spectrum of renal disease presenting with nephrotic syndrome has undergone a gradual change globally over the course of time. However, there still exist regional differences in the incidence of primary glomerular diseases causing adult onset nephrotic syndrome.Aim: To observe the spectrum of renal diseases presenting with adult onset nephrotic syndrome with comparative analysis of changing trends over the last five decades with regards to Western and Indian literature.Materials and Methods: Subjects included patients with age of 18-80 years presenting with nephrotic syndrome. Renal biopsies with immunofluoroscence studies were performed in all patients. Baseline clinical parameters of serum urea, creatinine, albumin, globulin, cholesterol, 24 hour urine protein and urine microscopy were recorded. Descriptive statistics was used and results were expressed as frequencies, percentages, and mean±standard deviation.Results: A total of 227 patients (72% males) were included for the study. Primary glomerular diseases formed 74.01% of total cases and majority of patients included males in the 4th decade. Minimal Change Disease (MCD) (15.8%) including its variants was the most common primary glomerular disease for adult onset of nephrotic syndrome followed by Mesangial proliferative Glomerulonephritis (MSGN) (13.2%). Membranous nephropathy and Type I Membranoproliferative Glomerulonephritis (MPGN) individually accounted for 12.3% of patients. Focal and Segmental Glomerulosclerosis (FSGS) accounted for only 11% of patients. Although, increased incidence of FSGS has been observed worldwide, there exist important regional differences in primary glomerular diseases in Indian population. MCD remains a major glomerular disease for adult onset nephrotic syndrome in different parts of India.Conclusion: Our study over three years represents important data of regional variations of primary glomerular diseases presenting with adult onset nephrotic syndrome.
机译：简介：伴有成年肾病综合征的原发性肾小球疾病是世界范围内慢性肾衰竭的主要原因。随着时间的流逝，呈现出肾病综合征的肾脏疾病的光谱在全球范围内经历了逐渐的变化。然而，引起成年肾病综合征的原发性肾小球疾病的发病率仍然存在区域差异。目的：观察近十年来西方成人与成年肾病综合征肾病的变化趋势，并进行比较分析材料和方法：受试者包括年龄在18-80岁之间的患有肾病综合征的患者。在所有患者中进行了带有免疫荧光检查的肾脏活检。记录血清尿素，肌酐，白蛋白，球蛋白，胆固醇，24小时尿蛋白和尿液镜检的基线临床参数。使用描述性统计，结果以频率，百分比和均值±标准差表示。结果：总共纳入227例患者（男性72％）。原发性肾小球疾病占总病例的74.01％，并且在第四十年中，大多数患者包括男性。最小变化疾病（MCD）（15.8％）及其变异是成人肾病综合征最常见的原发性肾小球疾病，其次是肾小球膜增生性肾小球肾炎（MSGN）（13.2％）。膜性肾病和I型膜增生性肾小球肾炎（MPGN）分别占患者的12.3％。局灶性和节段性肾小球硬化症（FSGS）仅占患者的11％。尽管在世界范围内已观察到FSGS的发病率增加，但印度人口中原发性肾小球疾病存在重要的地区差异。 MCD仍是印度不同地区成人成年肾病综合征的主要肾小球疾病。结论：我们三年来的研究代表了成人成年肾病综合征的原发性肾小球疾病区域变异的重要数据。

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