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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Evaluation of Serum Zinc, Copper Level and their Correlation with Cu/Zn Ratio and FT3/FT4 Ratio in Hypothyroidism
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Evaluation of Serum Zinc, Copper Level and their Correlation with Cu/Zn Ratio and FT3/FT4 Ratio in Hypothyroidism

机译：甲状腺功能减退症患者血清锌，铜水平及其与铜锌比和FT3 / FT4比的相关性评估

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Hypothyroidism is a condition characterised by deficiency of thyroid hormones due to defect in hormone synthesis pathway or development of resistance at the tissue level. It has been observed that trace elements may influence hormonal function at several levels. Various studies suggest that reduction in zinc and copper levels adversely affect the endocrine system.Aim: To determine the serum zinc and copper levels in hypothyroidism and its effect on the progression of hypothyroidism.Materials and Methods: The present case-control study was conducted among 80 hypothyroid patients and 80 apparently healthy individuals aged 18-55 years. Serum zinc (Zn) and copper (Cu) were measured by the colorimetric assay using semi-automated analyser. Free triiodothyronine (T3), free thyroxine (T4) and Thyroid stimulating hormone (TSH) were measured using the chemiluminiscence immunoassay method. Individual parameters by independent sample t-test and correlation was analysed by Pearson?s correlation test. The p-value <0.05 was considered significant.Results: No statistical difference was observed in the BMI among the two groups. Zinc levels in hypothyroid group (85.21 μg/dL) were significantly (p-value=0.002) lower as compared to the control group (100.83 μg/dL). However, copper levels in hypothyroid group (151.1 μg/dL) were increased as compared to the control group (140.5 μg/dL) but the difference was not statistically significant (p=0.09). In the hypothyroid patients, the Copper to Zinc (Cu/Zn) ratio was 1.7/1, which was higher than that of control group 1.3/1 (p-value=0.001). Zinc was found to be negatively correlated with TSH (r-value=-0.248; p-value=0.033) and positively correlated with FT4 (r-value=0.374; p-value=0.001). Cu/Zn ratio was found to have a weak positive correlation with FT3/FT4 ratio (r=0.0875; p-value=0.45).Conclusion: This study proved the presence of imbalance of trace elements like zinc and copper among hypothyroid patients and thereby emphasises on their importance in maintenance of thyroid homeostasis.
机译：甲状腺功能低下是一种疾病，其特征在于由于激素合成途径的缺陷或组织水平耐药性的发展而导致的甲状腺激素缺乏。已经观察到微量元素可能在几个水平上影响激素功能。各种研究表明，锌和铜水平的降低会对内分泌系统产生不利影响。目的：确定甲状腺功能减退症中的血清锌和铜水平及其对甲状腺功能减退的影响。材料和方法：本病例在80位甲状腺功能减退患者和80位年龄在18-55岁之间的健康人群中进行了对照研究。使用半自动化分析仪通过比色测定法测量血清锌（Zn）和铜（Cu）。使用化学发光免疫测定法测量游离三碘甲状腺素（T3），游离甲状腺素（T4）和甲状腺刺激激素（TSH）。通过独立样本t检验和相关性的各个参数通过Pearson相关检验进行分析。 p值<0.05被认为是显着的。结果：两组之间的BMI没有观察到统计学差异。甲状腺功能减退组的锌水平（85.21μg/ dL）与对照组（100.83μg/ dL）相比显着降低（p值= 0.002）。然而，甲状腺功能减退组的铜水平（151.1μg/ dL）比对照组（140.5μg/ dL）增加，但差异无统计学意义（p = 0.09）。甲状腺功能减退患者的铜锌比（Cu / Zn）为1.7 / 1，高于对照组1.3 / 1（p值= 0.001）。发现锌与TSH负相关（r值= -0.248; p值= 0.033），与FT4正相关（r值= 0.374; p值= 0.001）。发现铜锌比与FT3 / FT4比呈弱正相关（r = 0.0875; p值= 0.45）。结论：本研究证明甲状腺功能减退症中微量元素锌和铜不平衡患者并因此强调其在维持甲状腺稳态中的重要性。

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