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首页> 外文期刊>Journal of bacteriology >Inhibition of wall autolysis in Streptococcus faecalis by lipoteichoic acid and lipids.
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Inhibition of wall autolysis in Streptococcus faecalis by lipoteichoic acid and lipids.

机译：脂蛋白和脂类脂对粪便链球菌壁自溶的抑制作用。

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摘要

Fully acylated lipoteichoic acid (LTA) isolated from Streptococcus faecalis ATCC9790 (S. faecium) inhibited autolysis of walls from the same organism at concentrations (1.0 to 1.5 nmol of LTA per mg of wall) comparable to those found in intact cells. Partially deacylated LTA isolated from S. faecalis or chemically deacylated LTA failed to inhibit significantly in the same concentration range. Beef heart cardiolipin and commercially obtained dipalmitoyl phosphatidyl glycerol were also found to inhibit wall autolysis in S. faecalis. Chemical deacylation of beef heart cardiolipin also removed the inhibitory activity of this molecule. Lipid fractions isolated from S. faecalis that inhibited wall autolysis were: diphosphatidyl glycerol (cardiolipin), phosphatidyl glycerol, aminoacyl phosphatidyl glycerol, and a neutral lipid fraction. Glycolipids were not found to be effective inhibitors. The possible role of LTA and/or certain lipids as regulators of cellular autolytic activity is discussed.
机译：从粪链球菌ATCC9790（粪链球菌）中分离出来的完全酰化的脂磷壁酸（LTA）抑制了相同生物体壁的自溶，其浓度与完整细胞中的浓度相当（每毫克壁1.0至1.5 nmol LTA）。从粪链球菌分离的部分脱酰的LTA或化学脱酰的LTA在相同浓度范围内均无法显着抑制。牛肉心心磷脂和商购的二棕榈酰磷脂酰甘油也被发现抑制粪链球菌的壁自溶。牛肉心心磷脂的化学脱酰作用也消除了该分子的抑制活性。从粪链球菌分离的抑制壁自溶的脂质级分是：二磷脂酰甘油（心磷脂），磷脂酰甘油，氨酰基磷脂酰甘油和中性脂质组分。没有发现糖脂是有效的抑制剂。讨论了LTA和/或某些脂质作为细胞自溶活性调节剂的可能作用。

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