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首页> 外文期刊>Journal of bacteriology >C-factor has distinct aggregation and sporulation thresholds during Myxococcus development.
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C-factor has distinct aggregation and sporulation thresholds during Myxococcus development.

机译：在粘球菌的发展过程中，C因子具有不同的聚集和孢子形成阈值。

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C-factor, the protein product of the csgA gene, acts as a short-range morphogenetic signal. It is required for fruiting body development of the gram-negative bacterium Myxococcus xanthus. Aggregation, sporulation, and expression of a set of genes that are C-factor dependent, all of which fail in csgA mutant cells, are completely restored by addition of purified C-factor. We report here that, depending on its concentration, C-factor can elicit two distinct morphogenetic and transcriptional responses from csgA cells. Low levels of C-factor bring about aggregation and expression of an early C-dependent gene, whereas higher levels lead to the same effects plus expression of a late C-dependent gene and spore formation. C-factor positively regulates its own transcription. An approximately fourfold net increase in csgA transcription and C-factor levels during development was measured. We propose that autoregulation and the two distinct activity thresholds allow C-factor to act as a timer, first triggering aggregation, then sporulation, thereby producing the appropriate developmental order.
机译：C因子是csgA基因的蛋白质产物，可作为短程形态发生信号。它是革兰氏阴性细菌黄色葡萄球菌的子实体发育所必需的。通过添加纯化的C因子可完全恢复c因子依赖的一组基因的聚集，孢子形成和表达，这些基因均在csgA突变细胞中失败。我们在这里报告，根据其浓度，C因子可以引起csgA细胞两个不同的形态发生和转录反应。较低水平的C因子会导致早期C依赖性基因的聚集和表达，而较高水平的C因子会导致相同的作用以及晚期C依赖性基因的表达和孢子形成。 C因子积极调节其自身的转录。测量了发育过程中csgA转录和C因子水平的约四倍净增加。我们建议自动调节和两个不同的活动阈值允许C因子充当计时器，首先触发聚集，然后形成孢子，从而产生适当的发育顺序。

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