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Site of Action of Certain Antibacterial Heterocyclic Quaternary Ammonium Compounds

机译:某些抗菌杂环季铵化合物的作用部位

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The site of action of related mono- and bis-quinaldinium compounds was investigated in Staphylococcus aureus and Bacillus megaterium. The effects of these compounds on cell morphology and on protoplast formation and fragility were studied, and the distribution of C14-labeled quinaldinium compound in cell fractions was measured. The latter studies showed that a major part of the quaternary compound penetrates the cell, leaving a very small quantity associated with the cell wall. Similar antibacterial effects were seen with both the mono- and bis-quinaldinium compounds studied, and these effects were comparable with antibacterial properties of known cationic surface-active antibacterial agents.
机译:在金黄色葡萄球菌和甲硝酸芽孢杆菌中研究了相关单烯醇和双烯丙烯鎓化合物的作用。研究了这些化合物对细胞形态和原生质体形成和脆性的影响,并测量了C14标记氨基鎓化合物在细胞级分中的分布。后一种研究表明,季化合物的主要部分穿透细胞,留下与细胞壁相关的非常少量。通过研究的单烯丙基醌化合物可以看到类似的抗菌作用,并且这些效应与已知的阳离子表面活性抗菌剂的抗菌性能相当。

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