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Systematic review of the association between Alzheimer’s disease and chronic glaucoma

机译：阿尔茨海默病与慢性青光眼之间的系统综述

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Abstract: A potential association between Alzheimer’s disease (AD) and chronic glaucoma has been suggested but results of epidemiological studies have been inconsistent. Therefore, we performed a systematic review and critical appraisal of this literature. We searched systematically in PubMed from December 1964?to September 2013?and identified 239?articles potentially relevant for abstract and full-text review. Statistical heterogeneity (variability) across studies was evaluated using the Cochran Q test and the I2?statistic, and the Newcastle-Ottawa score was used to assess study quality. Ten studies were finally selected. Compared to non-demented participants, patients with AD had a statistically significant decreased risk of glaucoma but the results were very heterogeneous, and thus summary estimates were not reported (I2, 89%; Pheterogeneity, <0.001). The study results ranged from large positive relative risks identified in small and poorly-conducted studies to weak inverse associations or null estimates observed in some cohort and record-linkage studies, but the summary estimates were essentially driven by a large retrospective cohort using medical claims that may be afflicted by underdiagnosis bias. There was also evidence for substantial publication bias (Egger’s P≤0.01). The association of AD and glaucoma is heterogeneous and most studies are small and inadequately designed. Large prospective studies with long follow-ups are warranted to clarify this association.
机译：摘要：已经提出了阿尔茨海默病（AD）和慢性青光眼之间的潜在关联，但流行病学研究的结果一直不一致。因此，我们对该文献进行了系统审查和批判性评估。我们从1964年12月在Pubmed中系统地搜索？到2013年9月？并确定了239份？潜在与抽象和全文审查有关的文章。使用Cochran Q测试和I2统计评估跨研究的统计异质性（变异性），并使用纽卡斯尔 - 渥太华得分来评估研究质量。最终选择了十项研究。与非痴呆参与者相比，AD患者具有统计学上显着降低的青光眼风险，但结果非常异质，因此没有报告概要估计（I2,89％; pheterceney，<0.001）。该研究结果范围从小，对某些队列和记录连锁研究中观察到的弱逆关联或空估计中发现的弱反向关联或空估计中确定的研究结果范围，但总结估计数基本上由使用医疗权利要求的大型回顾性队列驱动可能受到欠诊断偏见的痛苦。还有实质性出版物偏见的证据（Egger的P≤0.01）。 AD和青光眼的关联是异质的，大多数研究都很小，设计不足。有必要澄清此协会的长期后续的大型前瞻性研究。

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