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Fibrinogen and thrombin concentrations are critical for fibrin glue adherence in rat high-risk colon anastomoses

机译：纤维蛋白原和凝血酶浓度对于大鼠高风险结肠吻合术中的纤维蛋白胶粘剂是关键的

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OBJECTIVE: Fibrin glues have not been consistently successful in preventing the dehiscence of high-risk colonic anastomoses. Fibrinogen and thrombin concentrations in glues determine their ability to function as sealants, healers, and/or adhesives. The objective of the current study was to compare the effects of different concentrations of fibrinogen and thrombin on bursting pressure, leaks, dehiscence, and morphology of high-risk ischemic colonic anastomoses using fibrin glue in rats. METHODS: Colonic anastomoses in adult female Sprague-Dawley rats (weight, 250-350 g) treated with fibrin glue containing different concentrations of fibrinogen and thrombin were evaluated at post-operative day 5. The interventions were low-risk (normal) or high-risk (ischemic) end-to-end colonic anastomoses using polypropylene sutures and topical application of fibrinogen at high (120 mg/mL) or low (40 mg/mL) concentrations and thrombin at high (1000 IU/mL) or low (500 IU/mL) concentrations. RESULTS: Ischemia alone, anastomosis alone, or both together reduced the bursting pressure. Glues containing a low fibrinogen concentration improved this parameter in all cases. High thrombin in combination with low fibrinogen also improved adherence exclusively in low-risk anastomoses. No differences were detected with respect to macroscopic parameters, histopathology, or hydroxyproline content at 5 days post-anastomosis. CONCLUSIONS: Fibrin glue with a low fibrinogen content normalizes the bursting pressure of high-risk ischemic left-colon anastomoses in rats at day 5 after surgery.
机译：目的：纤维蛋白胶水在预防高危结肠吻合的裂缝方面并未持续成功。胶原中的纤维蛋白原和凝血酶浓度决定了它们作为密封剂，愈合液和/或粘合剂的能力。目前研究的目的是比较不同浓度纤维蛋白原和血小板对大鼠纤维蛋白胶水抗损伤的压力，泄漏，裂开和形态对裂殖压力，泄漏，裂开和形态的影响。方法：在术后第5天评估用含有不同浓度纤维蛋白原和凝血酶处理的成年女性Sprague-Dawley大鼠（重量，250-350g）中的结肠吻合术（重量，250-350g）。干预措施是低风险（正常）或高的干预措施 - 使用聚丙烯缝合线和高（120mg / ml）浓度和高（1000IU / mL）或低（40mg / mL）或低（ 500 iu / ml）浓度。结果：单独缺血，单独吻合，或两者一起降低爆破压力。含有低纤维蛋白原浓度的胶水在所有情况下改善了该参数。高凝血酶与低纤维蛋白原组合也完全改善了低风险吻合的粘附。在吻合后5天的宏观参数，组织病理学或羟脯氨酸含量没有检测到差异。结论：具有低纤维蛋白原含量的纤维蛋白胶对手术后第5天在第5天在第5天在大鼠中的高危缺血性左旋环吻罩的爆破压力。

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