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首页> 外文期刊>Infection and Drug Resistance >Epidemic Characteristics of Carbapenem-Resistant Klebsiella pneumoniae in the Pediatric Intensive Care Unit of Yanbian University Hospital, China
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Epidemic Characteristics of Carbapenem-Resistant Klebsiella pneumoniae in the Pediatric Intensive Care Unit of Yanbian University Hospital, China

机译：中国延边大学医院儿科重症监护术中耐鲤鱼肺癌肺炎的流行特征

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Introduction: Carbapenem-resistant Enterobacteriaceae (CRE) pose a serious threat to clinical patient management and public health, as they are generally resistant to most antibiotics and cause infections with high mortality rates. Klebsiella pneumoniae ranks second among Enterobacteriaceae species that cause nosocomial infections. In this study, we investigated the epidemic characteristics of carbapenem-resistant K. pneumoniae (CRKP) in the pediatric intensive care unit (PICU) of Yanbian University Hospital. Materials and Methods: A total of 14 non-duplicate CRKP strains, collected from March 2015 to November 2019, were subjected to automated microbial identification and antimicrobial susceptibility tests using the Phoenix-100 ID/AST system. The strains were also subjected to genotypic resistance testing, polymerase chain reaction assays to detect genes encoding carbapenemases and other β-lactamases, multi-locus sequence typing (MLST), and pulsed-field gel electrophoresis (PFGE)-based homology analysis. Results: Two carbapenemase genes, KPC-2 and NDM-1 (in eight and six strains, respectively), were detected. MLST enabled the division of the strains into two sequence types, ST11 and ST1224 (containing eight and six strains, respectively). PFGE results classified the 14 strains into clonotypes A–D, of which clonotypes A and B belonged to ST11, while clonotypes C and D belonged to ST1224. Conclusion: Our study reveals that epidemics of the KPC-2-ST11 and NDM-1-ST1224 strains occurred in the PICU of Yanbian University Hospital. Surveillance and strict implementation of prevention and control measures are crucial to prevent the occurrence and rapid spread of nosocomial infections.
机译：简介：耐肠道肠杆菌（CRE）对临床患者管理和公共卫生构成严重威胁，因为它们通常对大多数抗生素具有抗性，并且导致具有高死亡率的感染。 Klebsiella肺炎在肠杆菌痤疮藻属中排名第二，导致医院感染。在这项研究中，我们研究了延边大学医院儿科重症监护室（PICU）的CarbapeNem抗性K.Pneumoniae（CRKP）的流行特征。材料和方法：从2015年3月到2019年11月收集的14个非重复的CRKP菌株，使用凤凰-100 ID / AST系统进行自动微生物鉴定和抗微生物敏感性试验。该菌株还进行基因型抗性测试，聚合酶链反应测定以检测编码碳结构酶和其他β-内酰胺酶，多基因座序列键入（MLST）和脉冲场凝胶电泳（PFGE）的同源性分析的基因。结果：检测到两种碳结甲酶基因，KPC-2和NDM-1（分别为8和八个菌株）。 MLST使菌株分为两个序列类型，ST11和ST1224（分别含有八个和六个菌株）。 PFGE结果将14个菌株分类为Clonotypes A-D，其中Clonotypes A和B属于ST11，而Clonotypes C和D属于ST1224。结论：我们的研究表明，KPC-2-ST11和NDM-1-ST1224菌株的流行病发生在延边大学医院的PICU中。监测和严格实施预防和控制措施至关重要，以防止医院感染的发生和快速传播。

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