...
首页> 外文期刊>International Journal of Environmental Research and Public Health >Effects of Short-Term Exposure to Particulate Air Pollutants on the Inflammatory Response and Respiratory Symptoms: A Panel Study in Schoolchildren from Rural Areas of Japan
【24h】

Effects of Short-Term Exposure to Particulate Air Pollutants on the Inflammatory Response and Respiratory Symptoms: A Panel Study in Schoolchildren from Rural Areas of Japan

机译:短期暴露在颗粒空气污染物对炎症反应和呼吸系统症状的影响:日本农村学童小组研究

获取原文
           

摘要

The relationship between particulate air pollutants and respiratory symptoms in children has not been consistent among studies, potentially owing to differences in the inflammatory response to different particulate air pollutants. This study aimed to investigate the effect of particulate air pollutants on respiratory symptoms and the inflammatory response in schoolchildren. Three hundred-and-sixty children were included in the study. The children recorded daily respiratory symptom scores for October 2015. In addition, the daily amount of interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α production was assessed in THP1 cells stimulated with suspended particulate matter (SPM), which was collected every day during the study period. Generalized estimating equation logistic regression analyses were used to estimate the associations among respiratory symptoms and the daily levels of SPM, IL-6, IL-8, and TNF-α. Daily SPM levels were not associated with respiratory symptoms or the daily IL-6, IL-8, and TNF-α levels. Conversely, there was a significant association between respiratory symptoms and the daily IL-6, IL-8, and TNF-α levels. These results suggested that the effects of particulate air pollutants on respiratory symptoms in schoolchildren might depend more on the pro-inflammatory response to them than on their mass concentration.
机译:儿童颗粒状空气污染物和呼吸系统症状之间的关系在研究中尚不一致,可能是由于对不同颗粒空气污染物的炎症反应的差异。本研究旨在探讨微粒空气污染物对呼吸系统症状的影响及学童炎症反应。研究中包含了三百六十个孩子。儿童记录了2015年10月的每日呼吸症状分数。此外,在用悬浮颗粒物质刺激的THP1细胞中评估白细胞介素(IL)-6,IL-8和肿瘤坏死因子(TNF)-α的每日量( SPM),每天在研究期间收集。广义估计方程逻辑回归分析用于估计呼吸系统症状的关联和SPM,IL-6,IL-8和TNF-α的日常水平。每日SPM水平与呼吸系统症状或每日IL-6,IL-8和TNF-α水平无关。相反,呼吸系统症状和每日IL-6,IL-8和TNF-α水平之间存在显着关联。这些结果表明,微粒空气污染物对学童中呼吸系统症状的影响可能比对它们的质量浓度更多地依赖于促炎症反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号