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首页> 外文期刊>Gastroenterology research and practice >Clinicopathologic Characteristics and Long-Term Outcome of Gastric Cancer Patients with Family History: Seven-Year Follow-Up Study for Korean Health Check-Up Subjects
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Clinicopathologic Characteristics and Long-Term Outcome of Gastric Cancer Patients with Family History: Seven-Year Follow-Up Study for Korean Health Check-Up Subjects

机译：胃癌患者的临床病理特征和长期结局的家族史：七年韩国卫生检查科目的七年后续研究

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Background/Aims. Family history (FHx) has been reported to be a risk factor for gastric cancer (GC). However, the long-term prognosis of GC with FHx remains controversial. We aimed to investigate the clinicopathologic characteristics and long-term outcomes of GC according to the presence or absence of GC FHx. Methods. This study was conducted on asymptomatic healthy individuals who underwent upper gastrointestinal endoscopy for the purpose of GC screening. Patients who were diagnosed with GC between October 2003 and December 2013 at Seoul National University Hospital Healthcare System Gangnam Center were identified. Demographic and clinicopathologic characteristics were compared between the groups with and without FHx of GC. Overall survival (OS) and recurrence-free survival (RFS) were assessed as primary outcomes. Results. There were no significant differences in tumor characteristics according to FHx of GC. However, preexisting adenoma was more frequent in patients with FHx than in those without FHx (14.5% vs. 6.3%, p=0.035). The proportion of patients with microsatellite instability (MSI) was also higher in groups with FHx of GC (43.2% vs. 13.2%, p=0.006). Helicobacter pylori infection rates of patients with FHx of GC tended to be higher although not significant (70.5% vs. 61.3%, p=0.188). However, OS and RFS at 5 years of the GC patients with FHx were not significantly different from those of patients without FHx. Conclusion. Preexisting adenoma and GC with MSI are more common in patients with FHx of GC than in those without. There were no significant differences in the survival rate according to FHx.
机译：背景/目标。据报道，家族史（FHX）是胃癌（GC）的危险因素。然而，GC与FHX的长期预后仍然存在争议。我们旨在根据GC FHX的存在或不存在调查GC的临床病理特征和长期结果。方法。本研究进行了用于对GC筛选的目的进行上胃肠内窥镜检查的无症状健康个体。确定了2003年10月和2013年12月在首尔国立大学医院医疗保健系统江南中心诊断出GC的患者。在具有和不含GC的FHX的组之间比较人口和临床病理学特征。将整体存活（OS）和复发存活（RFS）评估为主要结果。结果。根据GC的FHX，肿瘤特征没有显着差异。然而，在FHX的患者中预先存在的腺瘤比没有FHX的患者更频繁（14.5％与6.3％，P = 0.035）。微卫星不稳定性（MSI）的患者的比例在GC的FHX的基团中也较高（43.2％vs.13.2％，p = 0.006）。幽门螺杆菌感染率为GC的FHX患者往往更高，但虽然不显着（70.5％与61.3％，P = 0.188）。然而，在没有FHX的情况下，5年的GC患者的核心和rfs的GC患者没有显着差异。结论。预先存在的腺瘤和GC与MSI更常见于GC的FHX患者而不是那些没有。根据FHX的存活率没有显着差异。

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