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首页> 外文期刊>Microbiology >Bactericidal Activity of Streptomycin and Isoniazid in Combination with p-Aminosalicylic Acid against Mycobacterium tuberculosis
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Bactericidal Activity of Streptomycin and Isoniazid in Combination with p-Aminosalicylic Acid against Mycobacterium tuberculosis

机译：链氨基嘧啶和异喹啉与氨基水杨酸与结核分枝杆菌的杀菌活性

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SUMMARY: The bactericidal activity of streptomycin, isoniazid and combinations of streptomycin and isoniazid against tubercle bacilli growing in Tween albumin medium was measured with and without the addition of p-aminosalicylic acid (PAS). When the concentrations of these compounds were about 4 to 16 times their minimal inhibitory concentrations, PAS did not influence this activity, but it was slightly increased when the concentrations were 10 times higher (equal to peak serum concentrations in treated patients). Combinations of the low concentrations of PAS + streptomycin or PAS + isoniazid usually only delayed the emergence of drug-resistant bacilli, whereas combinations of the higher concentrations suppressed their growth.
机译：发明内容：用添加和加入对氨基水杨酸（PAS）测量链霉素和霉菌霉素和异烟霉素和异烟肼的杀菌活性和肌霉素和异烟杆菌的组合。当这些化合物的浓度为其最小抑制浓度的约4至16倍时，PAS不会影响该活性，但是当浓度高10倍时略微增加（等于治疗患者的峰血清浓度）。低浓度的PAS +链霉素或PAS +异烟肼的组合通常仅推迟耐药杆菌的出现，而较高浓度的组合抑制了它们的生长。

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