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首页> 外文期刊>Molecular imaging >Fluorescent, Plasmonic, and Radiotherapeutic Properties of the 177Lu–Dendrimer-AuNP–Folate–Bombesin Nanoprobe Located Inside Cancer Cells
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Fluorescent, Plasmonic, and Radiotherapeutic Properties of the 177Lu–Dendrimer-AuNP–Folate–Bombesin Nanoprobe Located Inside Cancer Cells

机译：177Lu-dendrimer-auanp-叶酸爆炸蛋白纳米骨蛋白位于癌细胞内的荧光，等离子体和放射治疗性质

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The integration of fluorescence and plasmonic properties into one molecule is of importance in developing multifunctional imaging and therapy nanoprobes. The aim of this research was to evaluate the fluorescent properties and the plasmonic–photothermal, therapeutic, and radiotherapeutic potential of 177Lu–dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity (177Lu–DenAuNP–folate–bombesin) when it is internalized in T47D breast cancer cells. The intense near-Infrared (NIR) fluorescence emitted at 825 nm from the conjugate inside cells corroborated the usefulness of DenAuNP–folate–bombesin for optical imaging. After laser irradiation, the presence of the nanosystem in cells caused a significant increase in the temperature of the medium (46.8°C, compared to 39.1°C without DenAuNP–folate–bombesin, P < 0.05), resulting in a significant decrease in cell viability (down to 16.51% ± 1.52%) due to the 177Lu–DenAuNP–folate–bombesin plasmonic properties. After treatment with 177Lu–DenAuNP–folate–bombesin, the T47D cell viability decreased 90% because of the radiation-absorbed dose (63.16 ± 4.20 Gy) delivered inside the cells. The 177Lu–DenAuNP–folate–bombesin nanoprobe internalized in cancer cells exhibited properties suitable for optical imaging, plasmonic–photothermal therapy, and targeted radiotherapy.
机译：荧光和等离子体性能的整合到一种分子中对于开发多功能成像和治疗纳米素是重要的。该研究的目的是评估177Lu-Dendimer的荧光性质和等离子体 - 光热，治疗和放射治疗潜力，与树突腔中的金纳米粒子（177Lu-Denaunp-Bombesin）缀合的177Lu-dendimer的末端和爆炸素。在T47D乳腺癌细胞中内化。从缀合物的缀合物中发射的强烈近红外（NIR）荧光来自细胞内的缀合物证实了DeNaunp-叶酸叶蛋白的用性进行了光学成像。激光照射后，细胞中纳米系统的存在导致培养基的温度显着增加（46.8℃，相比39.1°C而没有Denaunp-叶酸 - Bombesin，P <0.05），导致细胞显着降低由于177Lu-Denaunp-叶酸爆炸素等级，可行性（低至16.51％±1.52％）。在用1775-denaunp-叶酸叶蛋白蛋白处理后，T47D细胞活力降低了90％，因为在细胞内部输送的辐射吸收剂量（63.16±4.20gy）。 177Lu-denaunp-folate-bombesin纳米骨内化的癌细胞内化表现出适用于光学成像，等离子体光热疗和靶向放射疗法的性质。

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