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首页> 外文期刊>Nigerian Journal of Physiological Sciences >Dichlorvos induced oxidative and neuronal responses in rats: mitigative efficacy of iNigella sativa/i (Black Cumin)
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Dichlorvos induced oxidative and neuronal responses in rats: mitigative efficacy of iNigella sativa/i (Black Cumin)

机译：Dhichlorvos在大鼠中诱导氧化和神经元反应： Nigella sativa（黑孜然）的减轻疗效

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Poisoning from Organophosphates (OPs), especially Dichlorvos (DDVP) has become endemic due to the increasing use in house hold and agricultural pests control, with most marked effects in the nervous system. However, it is evidenced that natural antioxidants are efficacious against OPs toxicity. Thus, this study investigated the possible antidotal efficacy of Nigella sativa oil (NSO) in Dichlovos (DDVP) induced oxidative and neuronal damages in Wistar rats. DDVP was administered at sub-chronic daily dosage of 8.8 mg/kg.bw for 7 days and a post-administration of NSO at 1 ml/kg.bw for the subsequent 7 days. The rats were euthanized on the 15th day, blood sample collected via cardiac puncture, centrifuged and the plasma used for biochemical analysis of total antioxidant capacity (TAC), reduced glutathione (GSH) and total reactive oxygen species (ROS), while the frontal, occipital and cerebellar cortices and the medulla were removed for histo-morphological examinations. The results showed significant (P≤0.05) decrease in plasma TAC and GSH, while a significant (P≤0.05) increase in ROS was recorded, and some vacuolation around the neurons especially in the frontal and cerebellar cortices following DDVP exposure. However, post treatment with NSO was observed to be efficacious in the recovery of the oxidative activities and the neuro-architectural integrities. Thus, it can be concluded that the antioxidant capacity of NSO could be efficacious against OPs induced oxidative damages, especially in dichlorvos accidents.
机译：由于房屋持有和农业害虫控制的增加，有机磷酸盐（OPS），特别是Dhichlorvos（DDVP）的中毒已经变得流行，并且神经系统中具有最明显的效果。然而，它证明了天然抗氧化剂对OPS毒性有效。因此，本研究调查了Nigella Sativa油（NSO）在Wistar大鼠中诱导的氧化和神经元损伤中可能的抗病性疗效。 DDVP在亚慢性日剂量为8.8mg / kg.bw的7天，并在后续7天内以1ml / kg.bw在1ml / kg.bw的后给药。将大鼠在第15天进行安乐死，通过心脏穿刺收集的血液样品，离心和用于生化分析的总抗氧化能力（TAC），降低谷胱甘肽（GSH）和总反应性氧（ROS），而前置的血浆，除去枕骨和小粒细胞和髓质，用于组织形态检查。结果表明，血浆TAC和GSH的显着（p≤0.05）减少，而ROS的显着（p≤0.05）被记录，并且在DDVP暴露后的额头和小脑皮质中，围绕神经元的一些真空溶解。然而，观察到与NSO的后治疗在氧化活性和神经建筑完整性的回收中是有效的。因此，可以得出结论，NSO的抗氧化能力可能是有效的，适用于OPS诱导氧化损伤，特别是在Dhichlorvos事故中。

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