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Burden of Asthma in Elderly Japanese Patients: Using Hospital-Based Administrative Claims Data

机译：老年日本患者的哮喘负担：使用基于医院的行政权利要求

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IntroductionData are lacking on severe asthma burden in elderly people in Japan. We assessed the prevalence and clinical/economic burden of severe asthma and asthma-related hospitalizations in elderly and younger Japanese patients.MethodsThis retrospective study analyzed outpatient claims data and inpatient hospital discharge records among patients aged?≥?15?years with asthma (defined as?≥?2 prescriptions of inhaled corticosteroids [ICS] or ICS/long-acting beta-agonists [LABA]) between 1 July 2014 and 30 June 2017. We analyzed the outpatient visit assessment population with severe asthma (≥?240-day prescription of high-dose ICS and?≥?90-day prescription of?≥?1 additional controllers) and the asthma-related hospitalization population (≥?1 hospital admission[S] with a primary diagnosis of asthma/status asthmaticus and use of systemic corticosteroids) over a 1-year observation period before the date of each patient’s latest asthma prescription or asthma-related hospitalization within the study period. The primary outcome was the proportion of elderly (≥?65?years) and younger (15–39 and 40–64?years) patients among the outpatient visit assessment population. Secondary outcomes included outpatient and inpatient characteristics, asthma-related healthcare resource utilization, and asthma-associated costs, by age group.ResultsOf the outpatient visit assessment population ( n =?35,742), 4211 had severe asthma, with the prevalence of 8.2%, 12.8%, and 12.4% for the 15–39, 40–64, and?≥?65?years age groups, respectively. Elderly versus younger outpatients with severe asthma had higher cumulative oral corticosteroid doses. Among both outpatient visit assessment population and hospitalization assessment population, elderly versus younger outpatients with severe asthma or asthma-related hospitalizations had more comorbidities, required more biological, hematological, immunological, and microbiological tests, and incurred higher asthma-associated costs.ConclusionsIn addition to reaffirming the higher prevalence of severe asthma in Japanese patients?≥?40?years versus those??40?years of age, our results demonstrated higher clinical and economic burden in elderly versus younger patients.
机译：引入数据缺乏日本老年人的严重哮喘负担。我们评估了老年人和年轻患者严重哮喘和哮喘相关住院的患病率和临床/经济负担。近期的患者的门诊索赔数据和住院病院排放记录分析？≥？15？患有哮喘的患者（定义为？≥2-2Δ2在2014年7月1日和2017年6月30日之间吸入的皮质类固醇[ICS]或ICS /长效β-激动剂[Laba]）。我们分析了严重哮喘严重哮喘的门诊评估人口（≥240天高剂量IC和≥？90天的处方？≥？1个额外控制器）和哮喘相关住院人群（≥？1医院入院[S]，主要诊断哮喘/地位哮喘和使用系统皮质类固醇）在每位患者最新的哮喘处方或研究期内与哮喘相关住院日期之前的一个1年的观察期。主要结果是老年人（≥？65？年）和年轻（15-39和40-64岁）的比例，门诊访问评估人口中的患者。二次结果包括门诊和住院特征，哮喘相关的医疗资源利用以及年龄组的相关成本。门诊访问评估人口（n = 35,742），4211的哮喘严重，患病率为8.2％， 15-39,40-64和≥65？年龄组的12.8％和12.4％分别为年龄组。老年人与严重哮喘的年轻门诊患者具有更高的累积口腔皮质类固醇剂量。在门诊访问分析人口和住院评估人口中，老年人与具有严重哮喘或哮喘相关的住院治疗的年幼的门诊患者具有更多的合并症，所需的生物学，血液学，免疫学和微生物测试，并产生更高的哮喘相关成本。结论在日本患者中重申严重哮喘的患病率较高？≥？40？岁月与那些年龄？<？40？岁月，我们的结果表明老年人与较年轻患者的临床和经济负担更高。

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