Development of effective anti-inflammatory drug candidates among novel thiazolopyridines

T. I. Chaban; V. S. Matiychuk; V. V. Ogurtsov

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Development of effective anti-inflammatory drug candidates among novel thiazolopyridines

机译：新型噻唑吡啶中有效的抗炎药物候选者的发展

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In an effort to develop novel anti-inflammatory agents, a series of thiazolo[4,5- b ]pyridines were synthesized and modified at the Nsup3/sup position. The structures of the obtained compounds were confirmed by sup1/supH NMR spectroscopy and elemental analysis. The synthesized substances were preselected via molecular docking to be tested for their anti-inflammatory activity in vitro . Evaluation of compounds using the carrageenan-induced rat paw edema method showed strong anti-inflammatory action of some compounds ( 1 , 2 , 8 ) which exceeded that of ibuprofen.

机译：在努力开发新的抗炎剂，在N ^{3℃的位置合成并改性一系列噻唑烷[4,5- B]吡啶。通过 1-sp> H NMR光谱和元素分析证实所得化合物的结构。通过分子对接预选合成的物质，以测试其在体外的抗炎活性。使用角叉菜胶诱导的大鼠爪水肿方法的化合物评价显示出一些超过布洛芬的化合物（1,2,8）的强抗炎作用。}

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《Ukrainian Biochemical Journal》 |2020年第2期|共8页
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T. I. Chaban; V. S. Matiychuk; V. V. Ogurtsov;
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anti-inflammatory activitymolecular dockingorganic synthesisthiazolo45-bpyridines;

机译：抗炎活性分子分子池合成酶[45-b]吡啶;

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6. Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease [O] . Linshan Duan, Shuyu Cheng, Long Li, 2021

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7. Development of effective anti-inflammatory drug candidates among novel thiazolopyridines [O] . T. I. Chaban, V. S. Matiychuk, V. V. Ogurtsov, 2020

机译：新型噻唑吡啶中有效的抗炎药物候选者的发展

Development of effective anti-inflammatory drug candidates among novel thiazolopyridines

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