Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates.

Tributino JL; Duarte CD; Correa RS; Doriguetto AC; Ellena J; Romeiro NC; Castro NG; Miranda AL; Barreiro EJ; Fraga CA

首页> 外文期刊>Bioorganic and medicinal chemistry >Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates.

【24h】

Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates.

机译：新型6-甲磺酰胺-3,4-亚甲二氧基苯基-N-酰基hydr：口服有效的抗炎药候选物。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We described herein the molecular design of novel in vivo anti-inflammatory 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives (1) planned by applying the molecular hybridization approach. This work also points out to the discovery of LASSBio-930 (1c) as a novel anti-inflammatory and anti-hyperalgesic prototype, which was able to reduce carrageenan-induced rat paw edema with an ED(50) of 97.8 micromol/kg, acting mainly as a non-selective COX inhibitor.

机译：我们在本文中描述了通过应用分子杂交方法计划的新型体内抗炎性6-甲磺酰胺-3,4-亚甲二氧基苯基-N-酰基hydr衍生物的分子设计。这项工作还指出了LASSBio-930（1c）作为一种新型消炎和抗痛觉过敏原型的发现，该原型能够以97.8 micromol / kg的ED（50）减少角叉菜胶诱发的大鼠爪水肿，主要充当非选择性COX抑制剂。

著录项

来源
《Bioorganic and medicinal chemistry》 |2009年第3期|共7页
作者
Tributino JL; Duarte CD; Correa RS; Doriguetto AC; Ellena J; Romeiro NC; Castro NG; Miranda AL; Barreiro EJ; Fraga CA;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词
methanesulfonamide; novel; in vivo; umol;

机译：甲磺酰胺;新颖;体内;umol;

相似文献

外文文献
中文文献
专利

1. Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates. [J] . Tributino JL, Duarte CD, Correa RS, Bioorganic and medicinal chemistry . 2009,第3期

机译：新型6-甲磺酰胺-3,4-亚甲二氧基苯基-N-酰基hydr：口服有效的抗炎药候选物。
2. Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates. [J] . da Silva YK, Augusto CV, de Castro Barbosa ML, Bioorganic and medicinal chemistry . 2010,第14期

机译：吡嗪基酰肼衍生物的合成与药理评价设计为新型镇痛和抗炎药物候选物。
3. Molecular properties that influence the oral bioavailability of drug candidates. [J] . Veber DF, Johnson SR, Cheng HY, Journal of Medicinal Chemistry . 2002,第12期

机译：影响候选药物口服生物利用度的分子特性。
4. Effective low drug release using gold nanoparticles from chryseobacterium Spp against oral pathogens [C] . Subbaiya R, Ayyapadassan G., Kaviyadhivya R., Nanoscience, Engineering and Technology (ICONSET), 2011 International Conference on . 2011

机译：利用金黄色葡萄球菌中的金纳米颗粒对口腔病原体进行有效的低药物释放
5. Use of Topical Non-steroidal Anti-inflammatory Drugs to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions [D] . Alshaneqiti, Ishraq 2019

机译：使用非甾体类抗炎局部用药减轻口腔扁平苔藓和口腔苔藓样病变的疼痛
6. Randomized controlled trial to compare oral analgesic requirements and patient satisfaction in using oral non-steroidal anti-inflammatory drugs versus benzydamine hydrochloride oral rinses after mandibular third molar extraction: a pilot study [O] . Devalina Goswami, Gaurav Jain, Mangesh Mohod, 2018

机译：下颌第三磨牙拔牙后口服非甾体类抗炎药与盐酸苯乙胺口服冲洗液比较口服镇痛剂需求和患者满意度的随机对照试验：一项前瞻性研究
7. Oral Health-Related Quality of Life and the Use of Oral and Topical Nonsteroidal Anti-Inflammatory Drugs for Pericoronitis [O] . Abdullah Alalwani, Oğuz Buhara, Mustafa Şenol Tüzüm 2019

机译：与口腔健康有关的生活质量和使用口腔和局部非甾体抗炎药进行腹膜炎

Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates.

摘要

著录项

相似文献

相关主题

期刊订阅