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首页> 外文期刊>Journal of Clinical Medicine >Relative Skeletal Muscle Mass Is an Important Factor in Non-Alcoholic Fatty Liver Disease in Non-Obese Children and Adolescents
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Relative Skeletal Muscle Mass Is an Important Factor in Non-Alcoholic Fatty Liver Disease in Non-Obese Children and Adolescents

机译：相对骨骼肌肿块是非肥胖儿童和青少年非酒精性脂肪肝病的重要因素

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Recently, sarcopenia was identified as a risk factor for non-alcoholic fatty liver disease (NAFLD) in adults. We here investigated the association between skeletal muscle mass (SMM) and NAFLD in non-obese children and adolescents. A retrospective medical chart review was performed for individuals aged 9–15 years diagnosed with NAFLD. Healthy volunteers aged 9–15 years were recruited as controls. Participants were subject to laboratory tests, abdominal sonography, and multi-frequency bioelectrical impedance analysis. SMM data were calculated as the skeletal muscle-to-body fat ratio (MFR), and the diagnosis of fatty liver was established by abdominal sonography. The control and NAFLD groups included 73 and 53 individuals, respectively. No significant difference was observed in gender and body mass index (BMI) distribution between the groups. Mean MFR was significantly lower in individuals with NAFLD than in those without (0.83 vs. 1.04, p = 0.005). After adjusting for age, sex, BMI, and serum glucose, the risk of having NAFLD was significantly associated with a decreased MFR ( p = 0.016). NAFLD is significantly associated with relatively low SMM in non-obese children and adolescents. Increasing SMM, such as weight training, can be suggested as one of the treatment strategies in pediatric NAFLD without obesity.
机译：最近，Sarcopenia被鉴定为成年人中非酒精脂肪肝疾病（NAFLD）的危险因素。我们在这里研究了非肥胖儿童和青少年的骨骼肌质量（SMM）和NAFL之间的关联。对9-15岁诊断患有NAFLD的个体进行了回顾性的医疗图表。 9-15岁的健康志愿者被招募为控制。参与者受实验室测试，腹超声检查和多频生物电阻抗分析。 SMM数据被计算为骨骼肌对体脂肪比（MFR），腹超声检查建立了脂肪肝的诊断。控制和NAFLD分别包括73和53个个体。在组之间的性别和体重指数（BMI）分布中没有观察到显着差异。在没有（0.83 Vs.1.04，P = 0.005）的中，含有NAFLD的个体的平均MFR显着降低了调整年龄，性别，BMI和血清葡萄糖后，具有NAFLD的风险与减少的MFR显着相关（P = 0.016）。 NAFLD在非肥胖儿童和青少年中与相对低的SMM显着相关。增加SMM，如体重训练，可以作为儿科NAFLD的一种治疗策略而没有肥胖。

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