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Early Post-Stroke Infections Are Associated with an Impaired Function of Neutrophil Granulocytes

机译：早期后卒中后感染与中性粒细胞粒细胞的功能受损有关

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To investigate whether neutrophil granulocytes’ function relates to post-stroke infections and clinical outcome after stroke, we prospectively recruited 95 patients after ischemic stroke and tested them for their microbiocidal neutrophil functions in this exploratory study. Additionally, 24 age-adjusted controls were examined regarding neutrophil function. Phagocytic capacity and the ability of the neutrophil granulocytes to produce reactive oxygen species (ROS) as well as CD11b and CD16 receptor expression profile were measured by flow cytometry at days 1, 3, 7, and 90 after symptom onset. Primary outcome was the development of an infection within the first week after stroke. Results of neutrophil functional measurements were compared between patients with and without infection as well as between all stroke patients and controls. Further risk factors for the development of infections were summarized in an infection-risk score for the purpose of multivariate statistical analysis. The ROS production in neutrophils after stimulation with formyl-methionyl-leucyl-phenylalanine (fMLP) was reduced at baseline in patients with post-stroke infections compared to those without ( p = 0.013). This difference proved to be independent from the infection-risk score in the binary logistic regression ( p = 0.011). Phagocytosis and oxidative bursts were not significantly reduced in the whole stroke patient group compared to controls. Dysfunction of neutrophil granulocytes seems to play a significant role in the development of post-stroke infections. Further studies are warranted to investigate neutrophil granulocytes′ function as a potential biomarker of post-stroke infections.
机译：为了探讨中性粒细胞粒细胞的功能是否涉及中风后感染和中风后临床结果，我们在缺血性中风后促进了95名患者，并在该探索性研究中对其进行微生物中性粒细胞功能进行了测试。另外，研究了24种调节的对照，关于中性粒细胞功能。在症状发作后的第1,3,7和90天通过流式细胞术测量吞噬细胞粒细胞和中性粒细胞粒细胞产生反应性氧物质（ROS）以及CD16受体表达谱的能力。主要结果是在中风后的第一周内发育感染。患有嗜中性粒细胞功能测量的结果比较患者，无感染患者以及所有中风患者和对照组。为了多元统计分析，总结了在感染风险评分中总结了发育感染的进一步危险因素。与甲基 - 甲基 - 白甲酰苯丙氨酸（FMLP）刺激后的中性粒细胞的ROS产生在患有后冲程后感染的基线上降低了（P = 0.013）。这种差异被证明是独立于二进制物流回归中的感染风险评分（P = 0.011）。与对照相比，整个中风患者组中吞噬作用和氧化爆发未显着降低。中性粒细胞粒细胞的功能障碍似乎在中风后感染的发展中发挥着重要作用。需要进一步的研究来调查中性粒细胞粒细胞的功能作为卒中后感染的潜在生物标志物。

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