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首页> 外文期刊>Journal of King Saud University >Hyper-ovulation, endometriosis, and hyperplasia associated with tamoxifen exposure in Swiss albino mice
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Hyper-ovulation, endometriosis, and hyperplasia associated with tamoxifen exposure in Swiss albino mice

机译：超排卵，子宫内膜异位症和与瑞士白化小鼠的三种毒素暴露相关的增生

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摘要

The available literature on the safety profile of tamoxifen in human patients and in experimental animals is mostly contradictory. The present study was therefore, designed to understand the safety profile of tamoxifen using Swiss albino mice. Swiss albino mice of age 13?weeks were orally administered tamoxifen (35?mg/kg/day) for 80?days. The breast, liver, and ovaries were used to evaluate the toxicity of tamoxifen in these organs using histopathology by H& E staining, the organ indices, estimation of liver enzymes, sex hormones, and antioxidant enzymes were compared with control mice group. The histopathological profiles indicated that breasts of the treated mice were not affected; however, it caused major damage to the liver, uterus, and ovaries. Tamoxifen also induced a moderate level of apoptosis by elevating the level of caspase-3 in the liver, uterus, and ovaries of the treated mice. The estrogen and progesterone levels were also significantly reduced. Tamoxifen induced hyper ovulation in treated mice group which has never been reported before. These data suggest that hepatotoxicity and hyper ovulation associated with tamoxifen could not be overruled and hence an alternate hormone disruptors other than tamoxifen should be investigated.
机译：人类患者和实验动物在人类患者和实验动物中的安全性曲线的可用文献主要是矛盾的。因此，本研究旨在了解使用瑞士白化小鼠的Tamoxifen的安全性曲线。瑞士白血菌小鼠13岁？周是口服给药的Tamoxifen（35μmg/ kg /天）80？天。使用H＆E染色，使用H＆E染色，使用H＆E染色，器官索引，肝酶的估计，与对照小鼠进行对照小鼠，使用H＆E染色，器官索引，肝酶的估计和抗氧化酶的乳腺癌，肝脏和卵巢评估这些器官中的毒性。组织病理学谱表明处理过的小鼠的乳房不受影响;然而，它对肝脏，子宫和卵巢产生了重大损害。他莫昔芬还通过升高治疗小鼠的肝脏，子宫和卵巢中的Caspase-3水平来诱导中等细胞凋亡。雌激素和孕酮水平也显着降低。他莫昔芬诱导治疗小鼠组的超排卵，从未报道过。这些数据表明，与他莫昔芬相关的肝毒性和超排卵是不估计的，因此应该研究除他莫昔芬以外的交替激素破坏剂。

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