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首页> 外文期刊>International journal of infectious diseases : >Genetic diversity of Neisseria gonorrhoeae multi-antigen sequence types in Russia and Europe
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Genetic diversity of Neisseria gonorrhoeae multi-antigen sequence types in Russia and Europe

机译：俄罗斯和欧洲奈瑟奈瑟奈瑟肽多抗原序列类型的遗传多样性

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Objectives The goal of this work was to assess the genetic diversity of Neisseria gonorrhoeae isolates in Russia and Europe and to compare the distribution of the N. gonorrhoeae multi-antigen sequencing types (NG-MAST) of Russian isolates with that of isolates from European countries. Methods NG-MAST typing was performed for 804 N. gonorrhoeae isolates collected in Russia in 2013–2018. For isolates from European countries, data from the https://pathogen.watch/collection/eurogasp2013 database were used. Results Among the isolates from Russia, 296 NG-MAST types were found. A maximum likelihood phylogenetic tree was constructed. Phylogenetic analysis revealed seven major genogroups uniting the most frequent Russian sequence types: G807, G1993, G9476, G14942, G1152, G9486, and G12531. Conclusions The NG-MAST type distribution in Russia differed from that in European countries. Most of the Russian isolates had sequence types that were not found in Europe. Only 33% of the Russian isolates belonged to genogroups established for European countries, and the widespread European genogroup G1407 was represented by only nine isolates. Analysis of the Russian isolates belonging to phylogenetically close European genogroups indicated similarities in drug resistance, although no epidemically dangerous drug-resistant clones were found among the Russian isolates.
机译：目的这项工作的目标是评估俄罗斯和欧洲的奈瑟氏歌剧术孤立株的遗传多样性，并比较俄罗斯分离株的N.淋病术多抗原测序类型（NG-Mast）与欧洲国家的孤立液。方法在2013 - 2018年俄罗斯收集的804芽淋淋淋菌分离株进行NG-MAST打字。对于欧洲国家的孤立株，使用来自HTTPS://PathoLoOn.Watch/Collection/eUrogasp2013数据库的数据。结果来自俄罗斯的孤立株，发现了296种NG-MAST类型。构建了最大似然性系统。系统发育分析揭示了七种主要基因组，其中包括最常见的俄罗斯序列类型：G807，G1993，G9476，G14942，G1152，G9486和G12531。结论俄罗斯的NG-MAST型分布与欧洲国家不同。大多数俄罗斯孤立都有欧洲未发现的序列类型。只有33％的俄罗斯分离株属于为欧洲国家建立的Genogroups，而普遍的欧洲GenoGroup G1407仅由九个分离株代表。俄罗斯分离株属于欧洲的俄罗斯抗性欧洲基因组的分析表明耐药性的相似性，尽管俄罗斯分离株中没有发现尾病毒耐药克隆。

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