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首页> 外文期刊>International journal of infectious diseases : >Health economic assessment of a rabies pre-exposure prophylaxis program compared with post-exposure prophylaxis alone in high-risk age groups in the Philippines
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Health economic assessment of a rabies pre-exposure prophylaxis program compared with post-exposure prophylaxis alone in high-risk age groups in the Philippines

机译：狂犬病患者预防预防预防计划的健康经济评估与菲律宾的高风险年龄组中的暴露后预防患者相比

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Objectives Once symptoms appear, rabies is almost always fatal and accounts for 200–300 deaths annually in the Philippines. Available rabies vaccines can be administered either in pre- exposure prophylaxis (PrEP) or post-exposure prophylaxis (PEP). After exposure, PrEP-immunized individuals require fewer doses of PEP and no rabies immunoglobulin. Methods A static decision-tree model was developed to assess cost-effectiveness of a PrEP+PEP program vs PEP alone. Philippines-specific data for people seeking medical advice at the Research Institute for Tropical Medicine between July 2015 and June 2016 were used in the model, together with data from published literature. Results Over a 20-year period, in a cohort of 1 million 5-year-old children in the Philippines, PrEP+PEP was expected to prevent 297 deaths compared with PEP alone. From both payer and societal perspectives, the resulting incremental cost-effectiveness ratios were 36 035 (US$759; 2016 US$ conversion) and 18 663 (US$393) Philippine Pesos (PHP) — quality-adjusted life-years gained — respectively, which are both below the willingness-to-pay threshold of PHP140 255 (US$2 953). Conclusion These data suggest that a universal PrEP program targeting 5-year-olds would be cost-effective in the Philippines.
机译：目的出现症状一旦出现症状，狂犬病几乎总是致命，在菲律宾每年每年死亡，占200-300人死亡。可用的狂犬病疫苗可以在预防预防（预制）或暴露后的预防（PEP）中给药。暴露后，预防免疫的个体需要更少的PEP和NO狂犬病免疫球蛋白。方法制定了静态决策树模型，以评估预备+ PEP程序的成本效益VS PEP。菲律宾特定于2015年7月至2016年7月至2016年6月在2015年7月至2016年6月期间寻求医疗建议的人员的数据，并在该模型中使用来自出版文献的数据。结果在菲律宾的100万5岁儿童队列中，预计将预期预防297人死亡的队伍，而且单独预防297人死亡。从付款人和社会角度来看，由此产生的增量成本效益比率为36 035（2016年US $ 759; 2016美元转换）和18 663（US $ 393）菲律宾比索（PHP） - 分别获得质量调整的寿命年 - 均低于PHP140 255的愿意支付阈值（2953美元）。结论这些数据表明，针对5岁儿童的普遍准备计划将在菲律宾成本效益。

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