An efficient synthesis of 4,5-diaryl-3,4-dihydropyrimidin-2(1H)-one via a cesium carbonate-promoted direct condensation of 1-aryl-2-propanone with 1,1′-(arylmethylene)diurea

Yi-Cong Guo; Xuan-Di Song; Wei Deng; Weidong Rao; Haiyan Xu; Zhi-Liang Shen

首页> 外文期刊>RSC Advances >An efficient synthesis of 4,5-diaryl-3,4-dihydropyrimidin-2(1H)-one via a cesium carbonate-promoted direct condensation of 1-aryl-2-propanone with 1,1′-(arylmethylene)diurea

【24h】

An efficient synthesis of 4,5-diaryl-3,4-dihydropyrimidin-2(1H)-one via a cesium carbonate-promoted direct condensation of 1-aryl-2-propanone with 1,1′-(arylmethylene)diurea

机译：通过碳酸铯 - 促进的1-芳基-2-丙酮的直接缩合为1,1' - （芳基甲基）二脲，高效合成4,5-二芳基-3,4-二氢嘧啶-2（1H） - 酮

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

An efficient method for the synthesis of 4,5-diaryl-3,4-dihydropyrimidin-2(1 H )-one by using 1,1′-(arylmethylene)diurea and 1-aryl-2-propanone as substrates was developed. The reactions proceeded efficiently in the presence of Cs _(2) CO _(3) to give the desired products in moderate to good yields with wide substrate scope and good functional group tolerance, serving as an attractive alternative or complement to the previously reported methods for the facile assembly of biologically and pharmaceutically active 3,4-dihydropyrimidin-2(1 H )-ones.

机译：通过使用1,1' - （芳基亚甲基）DIUREA和1-芳基-2-丙酮作为基质的合成4,5-二芳基-3,4-二氢嘧啶-2（1H）-One的有效方法。反应在CS _（2）CO _（3）的存在下有效地进行，得到所需产物的中等至良好的产率，具有宽的基材范围和良好的官能团耐受性，用作先前报道的方法的有吸引力的替代或补充剂用于生物学和药物活性3,4-二氢嘧啶蛋白-2（1小时）酮的容纳组件。

著录项

来源
《RSC Advances》 |2020年第50期|共7页
作者
Yi-Cong Guo; Xuan-Di Song; Wei Deng; Weidong Rao; Haiyan Xu; Zhi-Liang Shen;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. An efficient synthesis of 4,5-diaryl-3,4-dihydropyrimidin-2(1H)-oneviaa cesium carbonate-promoted direct condensation of 1-aryl-2-propanone with 1,1 '-(arylmethylene)diurea [J] . Guo Yi-Cong, Song Xuan-Di, Deng Wei, RSC Advances . 2020,第50期

机译：高效合成4,5-二芳基-3,4-二氢嘧啶-2（1H） - 甘氨酸铯 - 碳酸铯 - 促进的1-芳基-2-丙酮的直接缩合为1,1' - （芳基甲基）Diurea
2. Nanosilica-bonded N-(propylsulfonyl) piperazine-N-sulfamic acid as recyclable catalyst for synthesis of 1,1 '-(arylmethylene) diureas and 1,3,5-triazinane-2,4-dithiones [J] . Rezaee Parizad, Davarpanah Jamal Research on Chemical Intermediates . 2016,第9期

机译：纳米二氧化硅键合的N-（丙基磺酰基）哌嗪-N-氨基磺酸作为可循环使用的催化剂，用于合成1,1'-（芳基亚甲基）双脲和1,3,5-三嗪烷-2,4-二硫酮
3. Triethylamine Promoted Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones Using a Solvent-Free Biginelli Condensation [J] . Debache A, Ghalem W, Boulcina R, Letters in organic chemistry . 2010,第4期

机译：三乙胺使用无溶剂的Biginelli缩合反应促进3,4-二氢嘧啶-2（1H）-酮/硫酮的高效合成
4. Efficient Synthesis of 3, 4-Dihydropyrimidin-2(1H)-Ketone Using SbCl_3 as Catalyst under Ultrasonic Conditions [C] . Jin Lin, Jing fen Li, BinbinZheng, International Conference on Energy Engineering and Environmental Engineering . 2013

机译：在超声波条件下，高效合成3,4-二氢嘧啶-2（1H） - 酮作为催化剂的SBCl_3
5. 1. Studies directed toward the synthesis of 20B-carbachaparrinone analogs via a samarium (II) iodide ring closure of a highly functionalized intermediate. 2. Synthesis of 5-oxo-cyclopent-1-enecarboxylic acid methyl esters via a novel tandem aldol-knoevenagel condensation. 3. Novel carbocyclic ring formation via intramolecular enol trapping of an allyl cation in acidic polar media. [D] . DeSelms, Robert Herschel. 2002

机译：1.研究针对通过高度官能化中间体的碘化sa（II）闭环合成20B-氨基苯甲酰吗啉酮类似物。 2.通过新型串联的羟醛-knoevenagel缩合合成5-氧代-环戊-1-烯羧酸甲酯。 3.通过在酸性极性介质中烯丙基阳离子的分子内烯醇捕获而形成新的碳环。
6. A Green Expeditious One-Pot Synthesis of 3 4-Dihydropyrimidin-2(1H)-ones Using a Mixture of Phosphorus Pentoxide-Methanesulfonic Acid at Ambient Temperature [O] . Amulrao Borse, Mahesh Patil, Nilesh Patil, 2012

机译：在环境温度下使用五氧化二磷-甲磺酸混合物进行绿色快速的一锅合成34-Dihydropyrimidin-2（1H）-ones
7. An Efficient, Eco-friendly and Sustainable One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Directly from Alcohols Catalyzed by Heteropolyanion-Based Ionic Liquids [O] . Renzhong Fu, Yang Yang, Xudong Ma, 2017

机译：一种高效，环保和可持续的单罐合成3,4-二氢嘧啶-2（1H） - 由催化基于杂氰基离子液体催化的醇

An efficient synthesis of 4,5-diaryl-3,4-dihydropyrimidin-2(1H)-one via a cesium carbonate-promoted direct condensation of 1-aryl-2-propanone with 1,1′-(arylmethylene)diurea

摘要

著录项

相似文献

相关主题

期刊订阅