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首页> 外文期刊>RSC Advances >Efficient production of citric acid in segmented fermentation using Aspergillus niger based on recycling of a pellet-dispersion strategy
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Efficient production of citric acid in segmented fermentation using Aspergillus niger based on recycling of a pellet-dispersion strategy

机译：基于颗粒分散策略的回收，使用曲霉尼格斯的分段发酵生产柠檬酸

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Citric acid (CA), as the most important platform compound, has attracted much attention because of its broad applications in many areas. Here, we constructed a segmentation fermentation process which effectively separated cell growth and CA production. Through a pellet-dispersion strategy, the CA yield decline caused by the mycelium structure of Aspergillus niger was solved. In particular, CA production was significantly increased from 70.3 g L ~(?1) to 97.0 g L ~(?1) . Furthermore, the segmentation fermentation conditions were optimized to improve the CA production. Evidence showed that the process was stable during ten batches of recycling fermentation in 5 L five-conjoined-fermenters, from which the CA yield even increased by 1.4 g L ~(?1) (by 1.26%) compared with the control. All of these results confirm that the strategy could enhance productivity and avoid the traditional long process (about 30 days) of seed culturing (including spore preparation). It could be also applied in other fermentation industries involving filamentous fungi.
机译：柠檬酸（CA），作为最重要的平台化合物，吸引，因为在许多领域的广泛应用备受关注。在这里，我们构建了分割发酵方法有效地分离出的细胞生长和CA生产。通过颗粒状分散的策略，由黑曲霉的菌丝体结构中的CA产量下降得到了解决。尤其是，CA产量显著从70.3克L〜（α1）增加至97.0克L〜（α1）。此外，分割发酵条件进行了优化，以提高生产CA。证据表明，该过程中在5L发酵回收十批是稳定的五联体发酵菌与对照组相比，从该CA产量甚至增加了1.4克L-〜（α1）（1.26％）。所有这些结果证实，该策略能够提高生产率，避免种子的传统漫长的过程（大约30天）培养（含孢子制剂）。这可能涉及丝状真菌等发酵工业中也有应用。

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