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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Study of Oxidative Stress and One Carbon Metabolism in Prostate Neoplasm in a Tertiary Care Hospital
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Study of Oxidative Stress and One Carbon Metabolism in Prostate Neoplasm in a Tertiary Care Hospital

机译：三级护理医院前列腺肿瘤中氧化应激和一种碳代谢的研究

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Prostate neoplasm is a major health problem globally since last two decades. Among the contributory factors in aetiopathogenesis, oxidative stress and one carbon metabolism are also important.Aim: To compare the serum level of vitamin B12, homocysteine and Malondialdehyde (MDA) between prostate cancer, Benign Prostatic Hyperplasia (BPH) and control subjects to find out the status of oxidative stress and one carbon metabolism in prostate tumours.Materials and Methods: Forty patients each with BPH and Prostate cancer along with 40 age matched healthy controls were selected in an observational cross-sectional study, attending the outpatient and inpatient Department of Urology, IPGMER, Kolkata, West Bengal, India, as per predetermined inclusion and exclusion criteria. Oxidative stress for these patients was estimated by measuring lipid peroxidation product MDA by Thiobarbituric Acid Reactive Substances (TBARS) assay with spectrophotometer. Vitamin B12 and homocysteine were also analysed as a marker of one carbon metabolism by chemiluminescent method. Biochemical parameters such as fasting and post prandial blood sugar, urea, creatinine and liver function tests were measured by autoanalyser to rule out diabetes and any underlying hepatic and renal pathology. All the data were then analysed using statistical software SPSS version 24. The groups were compared using student’s unpaired t-test and Pearson’s correlation coefficient was applied to observe the correlation between variables.Results: A statistically significant rise of oxidative stress was found in BPH and prostate cancer cases compared to age matched control. Regarding one carbon metabolism, this study fails to demonstrate any statistically significant difference of Vitamin B12 level between BPH and control as well as between prostate cancer and control group. However, high serum homocysteine is associated with both BPH and prostate cancer compared to controls.Conclusion: In the present study, statistically significant increase in oxidative stress and serum homocysteine level and no difference of serum vitamin B12 was found in BPH and prostate cancer cases compared to control group. Longitudinal studies are however required to establish any relationship and to investigate the potential role of homocysteine as a novel tumour marker.
机译：从过去二十年以来，前列腺肿瘤是全球的主要健康问题。 Aetiop病变中的贡献因素，氧化应激和一个碳代谢也很重要。目的：比较前列腺癌，良性前列腺增生（BPH）和对照受试者之间的维生素B12，同态和丙二醛（MDA）的血清水平寻找前列腺肿瘤中氧化应激和一种碳代谢的状态。材料和方法：在观察横截面研究中选择了四十名与BPH和前列腺癌的患者以及40岁匹配的健康对照，参加门诊和住院部门泌尿外科，IPGMER，加尔各答，西孟加拉邦，印度，按预定的包含和排斥标准。通过用分光光度计测量硫氨基吡啶酸反应性物质（TBARS）测定来估计这些患者的氧化应激。还通过化学发光法分析维生素B12和同型半胱氨酸作为一种碳代谢的标志物。通过自动置换器测量禁食和后肾血糖，尿素，肌酐和肝功能试验等生化参数，以排除糖尿病和任何潜在的肝癌和肾病学。然后使用统计软件SPSS版本24分析所有数据。使用学生的未配对T检验和Pearson的相关系数进行比较，以观察变量之间的相关性。结果：发现氧化胁迫的统计学显着升高在BPH和前列腺癌病例与年龄匹配控制相比。关于一种碳代谢，本研究未能在BPH和控制和前列腺癌和对照组之间证明维生素B12水平的任何统计学上显着差异。然而，与对照组相比，高血清同型半胱氨酸与BPH和前列腺癌有关。癌症病例与对照组相比。然而，需要纵向研究来建立任何关系并研究同型半胱氨酸作为新型肿瘤标志物的潜在作用。

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