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首页> 外文期刊>American Journal of Translational Research >N-acetylcysteine prevents orchiectomy-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence
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N-acetylcysteine prevents orchiectomy-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence

机译：N-乙酰半胱氨酸通过抑制氧化应激和骨细胞衰老来防止睾丸切除诱导的骨质疏松症

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摘要

Oxidative stress is associated with many diseases and has been found to induce DNA damage and cellular senescence. Numerous evidences support the detrimental effects of oxidative stress or cellular senescence on skeletal homeostasis. N-acetylcysteine (NAC) is a powerful antioxidant. However, it is unclear whether NAC can suppress orchiectomy (ORX)-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence. In this study, ORX mice were supplemented with/without NAC, and were compared with each other and with sham-operated mice. Our results showed that NAC could prevent ORX-induced osteoporosis by inhibiting oxidative stress, DNA damage, osteocyte senescence and senescence-associated secretory phenotype (SASP), subsequently stimulating osteoblastic bone formation and inhibiting osteoclastic bone resorption. The results from this study suggest that NAC could be considered as a potential therapeutic agent for prevention and treatment of osteoporosis caused by testosterone deficiency.
机译：氧化应激与许多疾病有关，已被发现诱导DNA损伤和细胞衰老。许多证据支持氧化应激或细胞衰老对骨骼稳态的不利影响。 N-乙酰半胱氨酸（NAC）是一种强大的抗氧化剂。然而，目前尚不清楚NAC是否可以通过抑制氧化应激和骨细胞衰老来抑制睾丸切除术（ORX）诱导的骨质疏松症。在该研究中，orx小鼠补充有/不含NAc，并彼此比较并用假手术小鼠进行比较。我们的研究结果表明，NAC可以通过抑制氧化应激，DNA损伤，骨细胞衰老和衰老相关的分泌表型（SASP），随后刺激骨细胞骨形成和抑制骨细胞骨吸收来预防ORX诱导的骨质疏松症。本研究结果表明，NAC可以被认为是预防和治疗睾酮缺乏引起的骨质疏松症的潜在治疗剂。

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