...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Cancer >Preoperative prognostic nutritional index predicts postoperative infectious complications and oncological outcomes after hepatectomy in intrahepatic cholangiocarcinoma
【24h】

Preoperative prognostic nutritional index predicts postoperative infectious complications and oncological outcomes after hepatectomy in intrahepatic cholangiocarcinoma

机译：术前预后营养指数预测肝切除术后肝切除术后术后感染性并发症和肿瘤学结果

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the surgical treatment of intrahepatic cholangiocarcinoma (ICC), postoperative complications may be predictive of long-term survival. This study aimed to identify an immune-nutritional index (INI) that can be used for preoperative prediction of complications. Multi-institutional data from 316 patients with ICC who had undergone surgical resection were retrospectively analysed, with a focus on various preoperative INIs. Severe complications (Clavien-Dindo grade III–V) were identified in 66 patients (20.8%), including Grade V complications in 7 patients (2.2%). Comparison of areas under the receiver operating characteristic curve (AUCs) among various INIs identified the prognostic nutritional index (PNI) as offering the highest predictive value for severe complications (AUC?=?0.609, cut-off?=?50, P?=?0.008). Multivariate analysis revealed PNI? 50 (odds ratio [OR]?=?2.22, P?=?0.013), hilar lesion (OR?=?2.46, P?=?0.026), and long operation time (OR?=?1.003, P?=?0.029) as independent risk factors for severe complications. In comparing a high-PNI group (PNI?≥?50, n?=?142) and a low-PNI group (PNI? 50, n?=?174), the low-PNI group showed higher rates of both major complications (27% vs. 13.4%; P?=?0.003) and infectious complications (14.9% vs. 3.5%; P?=?0.0021). Furthermore, median survival time and 1- and 5-year overall survival rates were 34.2?months and 77.4 and 33.8% in the low-PNI group, respectively, and 52.4?months and 89.3 and 47.5% in the high-PNI group, respectively (P?=?0.0017). Preoperative PNI appears useful as an INI correlating with postoperative severe complications and as a prognostic indicator for ICC.
机译：在肝内胆管癌（ICC）的外科治疗中，术后并发症可能是可预测的长期存活。本研究旨在鉴定可用于术前预测并发症的免疫营养指数（INI）。从316例ICC患者进行了多种机构数据，他们回顾性地分析了手术切除的患者，重点关注各种术前Inis。在66名患者（20.8％）中鉴定了严重的并发症（Clavien-Dindo级III-V），其中7名患者的V级并发症（2.2％）。各种Inis中接收器操作特征曲线（AUC）下的区域的比较鉴定了预后营养指数（PNI），为严重并发症的最高预测值（AUC？=？0.609，切断？=？50，P？= ？0.008）。多变量分析显示PNI？＆ 50（几率比[或]？=？2.22，P？= 0.013），肺门口病变（或？=？2.46，P？= 0.026），长时间的操作时间（或？=？1.003，P？=？ 0.029）作为严重并发症的独立危险因素。在比较高PNI组（PNI≥≤50，n？=α142）和低PNI组（PNIα= 50，N？= 174），低PNI组显示出较高的两者率主要并发症（27％与13.4％; p？= 0.003）和传染性并发​​症（14.9％vs.3.5％; p？= 0.0021）。此外，中位生存时间和1年和5年的总体存活率分别为34.2个月和77.4和33.8％，分别为52.4个月和89.3％，89.3％，47.5％ （p？= 0.0017）。术前PNI似乎可用作与术后严重并发症的INI相关，作为ICC的预后指标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号