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首页> 外文期刊>Nepal Journal of Biotechnology >Assessment of phytochemicals, antimicrobial, antioxidant and cytotoxicity activity of methanolic extract of Tinospora cordifolia (Gurjo)
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Assessment of phytochemicals, antimicrobial, antioxidant and cytotoxicity activity of methanolic extract of Tinospora cordifolia (Gurjo)

机译：inospora Cordifolia（Gurjo）甲醇提取物评估植物化学，抗微生物，抗氧化剂和细胞毒性活性

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Traditionally used medicinal plants are the major resources of biologically active metabolites which are widely used for the cure of numerous diseases especially in developing countries where health facilities are rare. Many plants are in use for centuries but there is not enough scientific evidence and exploration. This research is focused on phytochemicals, antibacterial, antioxidant and cytotoxicity activity analysis of one of the most commonly used ethnomedicine Tinospora cordifolia collected from the Kavrepalanchok district of Nepal. Phytochemicals analysis of methanol extract of T. cordifolia showed the presence of alkaloids, coumarin saponins, glycosides, reducing sugar, and triterpenes. Antibacterial activity performed by disc diffusion method exhibited the highest activity against Streptococcus with a zone of inhibition are 10.3mm, 8.5mm, 6.5mm, and 6mm at 200mg/ml, 100mg/ml, 50mg/ml, and 25mg/ml of concentration respectively. DPPH radical scavenging activity increased with increasing concentration of extract. When compared with ascorbic acid at equivalent concentration, the extract shows a lower scavenging profile (56.07% for the extract and 98.01% for ascorbic acid at 320 ppm). Cytotoxicity was evaluated in terms of LC50 (lethality concentration). The result showed that the extract of T. cordifolia was found to be toxic with an LC50 value of 232.64μg/ml. The bioactive component present in the plants could be the result of its pharmacological effects that support the traditional use of plants.
机译：传统使用的药用植物是生物活性代谢物的主要资源，广泛用于众多疾病的治疗，特别是在卫生设施罕见的发展中国家。几个世纪以来，许多植物都有，但没有足够的科学证据和探索。该研究专注于从尼泊尔Kavrapalanchok区收集的最常用的乙型尼科西孢子孢子孢子菌的植物化学，抗菌，抗氧化剂和细胞毒性分析。甲蛋白甲醇提取物分析T.Cordifolia的培养基分析显示存在生物碱，香豆素皂苷，糖苷，还原糖和三萜。通过盘扩散方法进行的抗菌活性表现出对抑制区的抗链球菌的最高活性为10.3mm，8.5mm，6.5mm和6mm，分别为200mg / ml，100mg / ml，50mg / ml和25mg / ml浓度。随着提取物浓度的增加，DPPH激进的清除活性增加。当与抗坏血酸相比以等效浓度相比，提取物显示出较低的清除曲线（提取物的56.07％，抗坏血酸为320ppm的98.01％）。根据LC50（致死浓度）评估细胞毒性。结果表明，发现T.T.T.Tedifolia的提取物有毒，LC50值为232.64μg/ ml。植物中存在的生物活性组分可能是其药理作用的结果，其支持传统使用植物。

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