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Application of an automatic segmentation method for evaluating cardiac structure doses received by breast radiotherapy patients

机译：一种自动分割方法在乳腺放射治疗患者接收心脏结构剂量评估中的应用

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Background and purpose Quantifying radiation dose to cardiac substructures is important for research on the etiology and prevention of complications following radiotherapy; however, segmentation of substructures is challenging. In this study we demonstrate the application of our atlas-based automatic segmentation method to breast cancer radiotherapy plans for generating radiation doses in support of late effects research. Material and methods We applied our segmentation method to contour heart substructures on the computed tomography (CT) images of 70 breast cancer patients who received external photon radiotherapy. Two cardiologists provided manual segmentation of the whole heart (WH), left/right atria, left/right ventricles, and left anterior descending artery (LAD). The automatically contours were compared with manual delineations to evaluate similarity in terms of geometry and dose. Results The mean Dice similarity coefficient between manual and automatic segmentations was 0.96 for the WH, 0.65 to 0.82 for the atria and ventricles, and 0.06 for the LAD. The mean average surface distance was 1.2?mm for the WH, 3.4 to 4.1?mm for the atria and ventricles, and 6.4?mm for the LAD. We found the dose to the cardiac substructures based on our automatic segmentation agrees with manual segmentation within expected observer variability. For left breast patients, the mean absolute difference in mean dose was 0.1?Gy for the WH, 0.2 to 0.7?Gy for the atria and ventricles, and 1.8?Gy for the LAD. For right breast patients, these values were 0.0?Gy, 0.1 to 0.4?Gy, and 0.4?Gy, respectively. Conclusion Our automatic segmentation method will facilitate the development of radiotherapy prescriptive criteria for mitigating cardiovascular complications.
机译：背景和用来对心脏子结构进行辐射剂量的目的对于研究放射治疗后的并发症的病因和预防的研究非常重要;然而，子结构的分割是具有挑战性的。在这项研究中，我们证明了我们的地图集的自动分段方法在乳腺癌放射治疗计划中的应用，以产生辐射剂量，以支持晚期效果研究。我们将我们的分割方法应用于在电脑癌症患者的计算机断层扫描（CT）图像上的轮廓心脏子结构，接受外部光子放射治疗。两位心脏病学家提供了整个心脏（WH），左/右心房，左/右心室和左前期下降动脉（LAD）的手动分割。将自动轮廓与手动划分进行比较，以评估几何形状和剂量的相似性。结果WH的手动和自动分段之间的平均骰子相似度系数为0.96，适用于ATRIA和脑室的0.65至0.82，以及LAD的0.06。对于ATRIA和脑室的WH，3.4至4.1mm，平均平均表面距离为1.2Ω·mm，3.4毫米。我们发现基于我们的自动分割的心脏子结构的剂量与预期观察者可变性内的手动分段一致。对于左乳房患者，平均剂量的平均绝对差异为0.1μl≤HWH，0.2〜0.7？GY为Atria和脑室，1.8？GY为LAD。对于右乳房患者，这些值分别为0.0≤0.0≤0.1至0.4μm，分别为0.4〜0.4μm。结论我们的自动分割方法将促进放射疗法的发展规范性标准，以减轻心血管并发症。

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