...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Neuroscience >Hypothetical molecular interconnection between type 2 diabetes and dyslexia
【24h】

Hypothetical molecular interconnection between type 2 diabetes and dyslexia

机译：2型糖尿病和综合症之间的假设分子互连

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dyslexia is one of the most common learning disabilities, especially among children. Type 2 diabetes is a metabolic disorder that affects a large population globally, with metabolic disorders. There have been several genes that are identified as causes of Dyslexia, and in recent studies, it has been found out that some of those genes are also involved in several metabolic pathways. For several years, it has been known that type 2 diabetes causes several neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. Furthermore, in several studies, it was suggested that type 2 diabetes also has some associations with learning disabilities. This raises the question of whether “Is there a connection between type 2 diabetes and dyslexia?”. In this study, this question is elaborated by linking their developmental processes via bioinformatics analysis about these two diseases individually and collectively. The literature review for dyslexia and type two diabetes was completed. As the result of this literature review, the genes that are associated to type 2 diabetes and dyslexia were identified. The biological pathways of dyslexia, and dyslexia associated genes, type 2 diabetes, and type 2 diabetes associated genes were identified. The association of these genes, regarding to their association with pathways were analysed, and using STRING database the gene associations were analysed and identified. The findings of this research included the interaction analysis via gene association, co-expression and protein–protein interaction. These findings clarified the interconnection between dyslexia and type 2 diabetes in molecular level and it will be the beginning of an answer regarding to the relationship between T2D and dyslexia. Finally, by improving the understanding this paper aims to open the way for the possible future approach to examine this hypothesis.
机译：阅读障碍是最常见的学习障碍之一，特别是儿童。 2型糖尿病是一种代谢紊乱，其具有代谢障碍的全球大群。有几种基因被鉴定为综合症的原因，并且在最近的研究中，已经发现一些这些基因也参与了几种代谢途径。几年来，已知2型糖尿病导致几种神经变性障碍，例如阿尔茨海默病和帕金森病。此外，在几项研究中，有人建议2型糖尿病也有一些与学习障碍的关联。这提出了“2型糖尿病和诵读与诵读之间的联系的问题的问题？”。在这项研究中，通过将它们的发育过程与单独和集体的关于这两种疾病联系起来，通过对这两种疾病联系起来，阐述了该问题。综合症和两种糖尿病的文献综述完成。由于该文献综述，鉴定了与2型糖尿病和综合症相关的基因。鉴定了综合症和综合症相关基因，2型糖尿病和2型糖尿病相关基因的生物途径。分析了这些基因的关联，关于它们与途径相关性，并使用串数据库进行分析并鉴定基因缔合。该研究的发现包括通过基因关联，共同表达和蛋白质 - 蛋白质相互作用的相互作用分析。这些发现阐明了综合症和分子水平的2型糖尿病之间的互连，这将是关于T2D和综合症之间关系的答案的开始。最后，通过改善本文的理解，旨在为可能的未来审查这一假设的方法开辟道路。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号