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首页> 外文期刊>Environmental Science & Technology >Environmentally Relevant Inoculum Concentrations Improve the Reliability of Persistent Assessments in Biodegradation Screening Tests
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Environmentally Relevant Inoculum Concentrations Improve the Reliability of Persistent Assessments in Biodegradation Screening Tests

机译：与环境有关的接种物浓度提高了生物降解筛选试验中持久性评估的可靠性

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摘要

Standard OECD biodegradation screening tests (BSTs) have not evolved at the same rate as regulatory concerns, which now place an increased emphasis on environmental persistence. Consequently, many chemicals are falsely assigned as being potentially persistent based on results from BSTs. The present study increased test duration and increased inoculum concentrations to more environmentally relevant levels to assess their impact on biodegradation outcome and intratest replicate variability for chemicals with known environmental persistence. Chemicals were assigned to potential persistence categories based on existing degradation data. These more environmentally relevant BSTs (erBSTs) improved the reliability of persistence assignment by reducing the high variability associated with these tests and the occurrence of failures at low inoculum concentrations due to the exclusion of specific degraders. Environmental fate was determined using a reference set of ~（14）C-labeled compounds with a range of potential environmental persistences, and full mass balance data were collated. The erBST correctly assigned five reference chemicals of known biode-gradabilities to their appropriate persistence category in contrast to a standard OECD Ready Biodegradation Test (RBTs, P < 0.05). The erBST was significantly more reproducible than an OECD RBT (ANOVA, P < 0.05), with more consistent rates and extent of biodegradation observed in the erBST.
机译：经合组织的标准生物降解筛选测试（BST）的发展速度与监管机构关注的发展速度不同，现在监管机构对环境的持久性越来越重视。因此，根据BST的结果，许多化学品被误认为具有潜在的持久性。本研究增加了测试持续时间，并将接种物浓度提高到与环境更相关的水平，以评估其对已知环境持久性的化学品对生物降解结果和测试内复制变异性的影响。根据现有的降解数据将化学物质划分为潜在的持久性类别。这些与环境更相关的BST（erBST）通过减少与这些测试相关的高可变性以及由于排除特定降解剂而在低接种浓度下发生故障而提高了持久性分配的可靠性。使用〜（14）C标记的参考化合物确定了环境命运，这些化合物具有一系列潜在的环境持久性，并比较了全部质量平衡数据。与标准的OECD就绪生物降解测试（RBT，P <0.05）相比，erBST将具有已知生物降解能力的五种参考化学品正确地分配给了其适当的持久性类别。 erBST的重现性明显高于OECD RBT（ANOVA，P <0.05），并且在erBST中观察到的生物降解速率和程度更一致。

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  • 来源
    《Environmental Science & Technology》 |2017年第5期|3065-3073|共9页
  • 作者

    Timothy J. Martin; Jason R. Snape; Abigail Bartram; Aidan Robson; Kishor Acharya; Russell J. Davenport;

  • 作者单位

    School of Civil Engineering and Geosciences, Cassie Building, Newcasde University, Newcastle upon Tyne, NE1 7RU, United Kingdom;

    AstraZeneca Global Environment, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, United Kingdom;

    School of Civil Engineering and Geosciences, Cassie Building, Newcasde University, Newcastle upon Tyne, NE1 7RU, United Kingdom;

    School of Civil Engineering and Geosciences, Cassie Building, Newcasde University, Newcastle upon Tyne, NE1 7RU, United Kingdom;

    School of Civil Engineering and Geosciences, Cassie Building, Newcasde University, Newcastle upon Tyne, NE1 7RU, United Kingdom;

    School of Civil Engineering and Geosciences, Cassie Building, Newcasde University, Newcastle upon Tyne, NE1 7RU, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-17 13:57:24

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